{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:54:45Z","timestamp":1790942085823,"version":"4.1.0"},"reference-count":21,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study compared the efficacy and safety of patupilone with those of pegylated liposomal doxorubicin (PLD) in patients with platinum-refractory or -resistant epithelial ovarian, primary fallopian tube, or primary peritoneal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients with three or fewer prior regimens were eligible if they had received first-line taxane\/platinum-based combination chemotherapy and were platinum refractory or resistant. Patients were randomly assigned to receive patupilone (10 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      intravenously every 3 weeks) or PLD (50 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      intravenously every 4 weeks).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 829 patients were randomly assigned (patupilone, n = 412; PLD, n = 417). There was no statistically significant difference in overall survival (OS), the primary end point, between the patupilone and PLD arms (P = .195; hazard ratio, 0.93; 95% CI, 0.79 to 1.09), with median OS rates of 13.2 and 12.7 months, respectively. Median progression-free survival was 3.7 months for both arms. The overall response rate (all partial responses) was higher in the patupilone arm than in the PLD arm (15.5% v 7.9%; odds ratio, 2.11; 95% CI, 1.36 to 3.29), although disease control rates were similar (59.5% v 56.3%, respectively). Frequently observed adverse events (AEs) of any grade included diarrhea (85.3%) and peripheral neuropathy (39.3%) in the patupilone arm and mucositis\/stomatitis (43%) and hand-foot syndrome (41.8%) in the PLD arm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patupilone did not demonstrate significant improvement in OS compared with the active control, PLD. No new or unexpected serious AEs were identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2011.38.8082","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T02:40:08Z","timestamp":1347936008000},"page":"3841-3847","source":"Crossref","is-referenced-by-count":101,"title":["Randomized, Open-Label, Phase III Study Comparing Patupilone (EPO906) With Pegylated Liposomal Doxorubicin in Platinum-Refractory or -Resistant Patients With Recurrent Epithelial Ovarian, Primary Fallopian Tube, or Primary Peritoneal Cancer"],"prefix":"10.1200","volume":"30","author":[{"given":"Nicoletta","family":"Colombo","sequence":"first","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Kutarska","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meletios","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Soo","family":"Bae","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Rzepka-Gorska","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Bidzinski","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. Marii Sklodowskiej-Curie, Warszawa, Poland; Meletios Dimopoulos and Aristotelis Bamias, University of Athens, Athens, Greece; Duk-Soo Bae, Sungkyunkwan University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Nicoletta Colombo, University of Milan-Bicocca and European Institute of Oncology, Milan; Giovanni Scambia, Policlinico Universitario A. Gemelli, Rome, Italy; Elzbieta Kutarska, Centrum Onkologii Ziemi Lubelskej, Lublin; Izabella Rzepka-Gorska, Pomeranian Medical University of Szczecin, Szczecin; Mariusz Bidzinski, Centrum Onkologi-Instytut im. 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