{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:41:49Z","timestamp":1792190509604,"version":"4.4.0"},"reference-count":61,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Alternatives to cytotoxic agents are desirable for patients with HIV-associated Kaposi's sarcoma (KS). Vascular endothelial growth factor-A (VEGF-A) contributes to KS pathogenesis. We evaluated the humanized anti\u2013VEGF-A monoclonal antibody, bevacizumab, in patients with HIV-KS. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with HIV-KS who either experienced progression while receiving highly active antiretroviral therapy (HAART) for at least 1 month or did not regress despite HAART for at least 4 months were administered bevacizumab 15 mg\/kg intravenously on days 1 and 8 and then every 3 weeks. The primary objective was assessment of antitumor activity using modified AIDS Clinical Trial Group (ACTG) criteria for HIV-KS. HIV-uninfected patients were also eligible and observed separately. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Seventeen HIV-infected patients were enrolled. Fourteen patients had been receiving effective HAART for at least 6 months (median, 1 year). Thirteen patients had advanced disease (ACTG T<jats:sub>1<\/jats:sub>), 13 patients had received prior chemotherapy for KS, and seven patients had CD4 count less than 200 cells\/\u03bcL. Median number of cycles was 10 (range, 1 to 37 cycles); median follow-up was 8.3 months (range, 3 to 36 months). Of 16 assessable patients, best tumor responses observed were complete response (CR) in three patients (19%), partial response (PR) in two patients (12%), stable disease in nine patients (56%), and progressive disease in two patients (12%). Overall response rate (CR + PR) was 31% (95% CI, 11% to 58.7%). Four of five responders had received prior chemotherapy for KS. Over 202 cycles, grade 3 to 4 adverse events at least possibly attributed to therapy included hypertension (n = 7), neutropenia (n = 5), cellulitis (n = 3), and headache (n = 2). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Bevacizumab is tolerated in patients with HIV-KS and has activity in a subset of patients. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.39.6853","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T05:20:56Z","timestamp":1332220856000},"page":"1476-1483","source":"Crossref","is-referenced-by-count":113,"title":["Phase II Study of Bevacizumab in Patients With HIV-Associated Kaposi's Sarcoma Receiving Antiretroviral Therapy"],"prefix":"10.1200","volume":"30","author":[{"given":"Thomas S.","family":"Uldrick","sequence":"first","affiliation":[{"name":"Thomas S. Uldrick, Kathleen M. Wyvill, Pallavi Kumar, Deirdre O'Mahony, Wendy Bernstein, Karen Aleman, Mark N. Polizzotto, Seth M. 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