{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:54:46Z","timestamp":1791125686691,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,11,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Body mass index (BMI) was analyzed in 179 survivors by category (underweight, healthy-weight, overweight, and obese) and by z score. Fat and lean body mass measured by dual-energy x-ray absorptiometry was analyzed as z scores. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Over a median 6.6 years of follow-up, BMI z scores diminished significantly (0.32 pre-HSCT v \u22120.60 at 10 years post-HSCT; P &lt; .001). Mean z scores for fat mass stayed within population norms, but those for lean mass remained below normal levels and diminished significantly over time (P = .018). Pre-HSCT BMI category and\/or z score were strongly predictive of post-HSCT BMI (P &lt; .001) and of fat and lean mass z scores (both P &lt; .001). Survivors with extensive chronic graft-versus-host disease were more likely than others to have low BMI (P = .004) and low lean mass (P &lt; .001) post-HSCT. Older age at HSCT (P = .015) and T-cell\u2013depleted graft (P = .018) were predictive of lower post-HSCT BMI. Female patients had higher body fat (P = .002) and lower lean mass (P = .013) z scores than male patients, and black patients had higher fat mass z scores than white patients (P = .026). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> BMI declines significantly after allogeneic HSCT for childhood hematologic malignancies, reflecting primarily a substantial decrease in lean mass but not fat mass. Monitoring and preservation of BMI and lean mass are vital, especially in those with the identified risk factors. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.40.0457","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T06:40:01Z","timestamp":1349160001000},"page":"3991-3997","source":"Crossref","is-referenced-by-count":57,"title":["Longitudinal Changes in Body Mass and Composition in Survivors of Childhood Hematologic Malignancies After Allogeneic Hematopoietic Stem-Cell Transplantation"],"prefix":"10.1200","volume":"30","author":[{"given":"Hiroto","family":"Inaba","sequence":"first","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue C.","family":"Kaste","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Hartford","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan S.","family":"Motosue","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Chemaitilly","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Triplett","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Shook","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hon","family":"Pui","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing","family":"Leung","sequence":"additional","affiliation":[{"name":"Hiroto Inaba, Jie Yang, Sue C. Kaste, Christine M. Hartford, Megan S. Motosue, Wassim Chemaitilly, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, and Wing Leung, St Jude Children's Research Hospital; Hiroto Inaba, Sue C. Kaste, Brandon M. Triplett, David R. Shook, Ching-Hon Pui, Wing Leung, University of Tennessee Health Science Center, Memphis, TN; Jie Yang, Stony Brook University, Stony Brook, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052638"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-333070"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2231"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082933"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31812f864d"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.09.017"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331835"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.18.3273"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/35007508"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2014"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2012"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701769"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702718"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401818"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007038"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705694"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.068"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.8709"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3527"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91980-3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703352"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705268"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200102270-00007"},{"key":"B27","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1182\/blood.V93.6.2013.406k25_2013_2024","volume":"93","author":"Cohen A","year":"1999","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00622.x"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/adc.73.2.136"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.2003"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0048"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.152"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27389"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.09.016"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2011.40.0457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:12:50Z","timestamp":1653520370000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2011.40.0457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,10]]},"references-count":33,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2012,11,10]]}},"alternative-id":["10.1200\/JCO.2011.40.0457"],"URL":"https:\/\/doi.org\/10.1200\/jco.2011.40.0457","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,10]]}}}