{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:46:49Z","timestamp":1789958809310,"version":"4.0.1"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,12,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> The association between initial molecular response and longer-term outcomes with nilotinib was examined. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with imatinib-resistant or -intolerant chronic myeloid leukemia in chronic phase from the phase II nilotinib registration study with available postbaseline BCR-ABL1 transcript assessments were included (N = 237). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> BCR-ABL1 transcript levels (International Scale [IS]) at 3 months correlated with complete cytogenetic response (CCyR) by 24 months. Patients with BCR-ABL1 (IS) of &gt; 1% to \u2264 10% at 3 months with nilotinib had higher cumulative incidence of CCyR by 24 months than patients with BCR-ABL1 (IS) of &gt; 10% (53% v 16%). BCR-ABL1 (IS) at 3 months predicted major molecular response (MMR) by 24 months. Cumulative incidence of MMR by 24 months for patients with BCR-ABL1 (IS) of &gt; 0.1% to \u2264 1%, &gt; 1% to \u2264 10%, and &gt; 10% was 65%, 27%, and 9%, respectively. These differences were observed for patients with or without baseline BCR\u2013ABL1 mutations and for those with imatinib resistance or intolerance. Estimated event-free survival (EFS) rates at 24 months decreased with higher transcript levels at 3 months; patients with BCR-ABL1 (IS) of \u2264 1% had an estimated 24-month EFS rate of 82%, compared with 70% for patients with BCR-ABL1 (IS) of &gt; 1% to \u2264 10% and 48% for patients with BCR-ABL1 (IS) of &gt; 10%. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Patients with BCR-ABL1 (IS) of &gt; 10% at 3 months had a lower cumulative incidence of CCyR and MMR and lower rates of EFS versus patients with BCR-ABL1 (IS) of \u2264 10%. Prospective studies may determine whether close monitoring or alternative therapies are warranted for patients with minimal initial molecular response. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.40.5217","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T05:50:03Z","timestamp":1351576203000},"page":"4323-4329","source":"Crossref","is-referenced-by-count":83,"title":["Initial Molecular Response at 3 Months May Predict Both Response and Event-Free Survival at 24 Months in Imatinib-Resistant or -Intolerant Patients With Philadelphia Chromosome\u2013Positive Chronic Myeloid Leukemia in Chronic Phase Treated With Nilotinib"],"prefix":"10.1200","volume":"30","author":[{"given":"Susan","family":"Branford","sequence":"first","affiliation":[{"name":"Susan Branford, Centre for Cancer Biology, SA Pathology, University of Adelaide; Timothy P. Hughes, Royal Adelaide Hospital, Adelaide, Australia; Dong-Wook Kim, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea; Simona Soverini and Giovanni Martinelli, University of Bologna, Bologna; Giuseppe Saglio, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy; Ariful Haque and Richard C. Woodman, Novartis, East Hanover, NJ; Yaping Shou, Novartis, Cambridge, MA; Hagop M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Susan Branford, Centre for Cancer Biology, SA Pathology, University of Adelaide; Timothy P. Hughes, Royal Adelaide Hospital, Adelaide, Australia; Dong-Wook Kim, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Korea; Simona Soverini and Giovanni Martinelli, University of Bologna, Bologna; Giuseppe Saglio, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, Italy; Ariful Haque and Richard C. 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