{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:03:11Z","timestamp":1790985791373,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,11,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This report analyzes 4,760 patients with breast cancer randomly assigned to 5 years of monotherapy with letrozole or tamoxifen in the BIG 1-98 trial with available information on BMI at randomization. Multivariable Cox modeling assessed the association of BMI with disease-free survival, overall survival (OS), breast cancer\u2013free interval, and distant recurrence-free interval and tested for treatment-by-BMI interaction. Median follow-up was 8.7 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen percent of patients have died. Obese patients (BMI \u2265 30 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) had slightly poorer OS (hazard ratio [HR] = 1.19; 95% CI, 0.99 to 1.44) than patients with normal BMI (&lt; 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), whereas no trend in OS was observed in overweight (BMI 25 to &lt; 30 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) versus normal-weight patients (HR = 1.02; 95% CI, 0.86 to 1.20). Treatment-by-BMI interactions were not statistically significant. The HRs for OS comparing obese versus normal BMI were HR = 1.22 (95% CI, 0.93 to 1.60) and HR = 1.18 (95% CI, 0.91 to 1.52) in the letrozole and tamoxifen groups, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was no evidence that the benefit of letrozole over tamoxifen differed according to patients' BMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2011.40.8666","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T01:34:35Z","timestamp":1349746475000},"page":"3967-3975","source":"Crossref","is-referenced-by-count":118,"title":["Obesity and Risk of Recurrence or Death After Adjuvant Endocrine Therapy With Letrozole or Tamoxifen in the Breast International Group 1-98 Trial"],"prefix":"10.1200","volume":"30","author":[{"given":"Marianne","family":"Ewertz","sequence":"first","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn P.","family":"Gray","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith M.","family":"Regan","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent","family":"Ejlertsen","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen N.","family":"Price","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Th\u00fcrlimann","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Bonnefoi","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. Regan, International Breast Cancer Study Group (IBCSG) Statistical Center, Dana-Farber Cancer Institute, and Harvard Medical School; Karen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Paridaens","sequence":"additional","affiliation":[{"name":"Marianne Ewertz, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense; Bent Ejlertsen, Danish Breast Cancer Cooperative Group Statistical Center and Rigshospitalet, Copenhagen University Hospital; Henning Mouridsen, Danish Breast Cancer Cooperative Group, Rigshospitalet, Copenhagen, Denmark; Kathryn P. Gray and Meredith M. 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