{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:28:26Z","timestamp":1771234106586,"version":"3.50.1"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"Purpose<\/jats:title>To evaluate the prognostic value of ecotropic viral integration 1 gene (EVI1) overexpression in acute myeloid leukemia (AML) with MLL gene rearrangements.<\/jats:p><\/jats:sec>Patients and Methods<\/jats:title>We identified 286 patients with AML with t(11q23) enrolled onto German-Austrian Acute Myeloid Leukemia Study Group and Dutch-Belgian-Swiss Hemato-Oncology Cooperative Group prospective treatment trials. Material was available from 177 AML patients for EVI1 expression analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>We divided 286 MLL-rearranged AMLs into three subgroups: t(9;11)(p22;q23) (44.8%), t(6;11)(q27;q23) (14.7%), and t(v;11q23) (40.5%). EVI1 overexpression (EVI1+<\/jats:sup>) was found in 45.8% of all patients with t(11q23), with t(6;11) showing the highest frequency (83.9%), followed by t(9;11) at 40.0%, and t(v;11q23) at 34.8%. Concurrent gene mutations were rare or absent in all three subgroups. Within all t(11q23) AMLs, EVI1+<\/jats:sup>was the sole prognostic factor, predicting for inferior overall survival (OS; hazard ratio [HR], 2.06; P = .003), relapse-free survival (HR, 2.28; P = .002), and event-free survival (HR, 1.79; P = .009). EVI1+<\/jats:sup>AMLs with t(11q23) in first complete remission (CR) had a significantly better outcome after allogeneic transplantation compared with other consolidation therapies (5-year OS, 54.7% v 0%; Mantel-Byar, P = .0006). EVI1\u2212<\/jats:sup>t(9;11) AMLs had lower WBC counts, more commonly FAB M5 morphology, and frequently had additional trisomy 8 (39.6%; P < .001). Among t(9;11) AMLs, EVI1+<\/jats:sup>again was the sole independent adverse prognostic factor for survival.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Deregulated EVI1 expression defines poor prognostic subsets among AML with t(11q23) and AML with t(9;11)(p22;q23). Patients with EVI1+<\/jats:sup>MLL-rearranged AML seem to benefit from allogeneic transplantation in first CR.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.41.5505","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T17:00:50Z","timestamp":1348592450000},"page":"95-103","source":"Crossref","is-referenced-by-count":90,"title":["Deregulated Expression ofEVI1<\/i>Defines a Poor Prognostic Subset ofMLL<\/i>-Rearranged Acute Myeloid Leukemias: A Study of the German-Austrian Acute Myeloid Leukemia Study Group and the Dutch-Belgian-Swiss HOVON\/SAKK Cooperative Group"],"prefix":"10.1200","volume":"31","author":[{"given":"Stefan","family":"Gr\u00f6schel","sequence":"first","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Schlenk","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Engelmann","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Rockova","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Teleanu","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.M.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Eiwen","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Erpelinck","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije","family":"Havermans","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"L\u00fcbbert","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Germing","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo G.H.","family":"Schmidt-Wolf","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Berna","family":"Beverloo","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit J.","family":"Schuurhuis","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert J.","family":"Ossenkoppele","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Schlegelberger","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo F.","family":"Verdonck","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edo","family":"Vellenga","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Pabst","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bargetzi","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Krauter","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. 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Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.M.","family":"Valk","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"L\u00f6wenberg","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. Schmidt-Wolf, University of Bonn, Bonn; Brigitte Schlegelberger, J\u00fcrgen Krauter, Arnold Ganser, Hannover Medical School, Hannover, Germany; Veronika Rockova, Claudia Erpelinck, Marije Havermans, H...."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstanze","family":"D\u00f6hner","sequence":"additional","affiliation":[{"name":"Stefan Gr\u00f6schel, Richard F. Schlenk, Jan Engelmann, Veronica Teleanu, Michael W.M. K\u00fchn, Karina Eiwen, Konstanze D\u00f6hner, Hartmut D\u00f6hner, University Hospital Ulm, Ulm; Michael L\u00fcbbert, University of Freiburg Medical Center, Freiburg; Ulrich Germing, Heinrich-Heine-University of D\u00fcsseldorf, D\u00fcsseldorf; Ingo G.H. 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