{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:55:26Z","timestamp":1791424526576,"version":"4.3.3"},"reference-count":42,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,7,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Gemcitabine plus cisplatin is active in malignant mesothelioma (MM), although single-arm phase II trials have reported variable outcomes. Vascular endothelial growth factor (VEGF) inhibitors have activity against MM in preclinical models. We added the anti-VEGF antibody bevacizumab to gemcitabine\/cisplatin in a multicenter, double-blind, placebo-controlled randomized phase II trial in patients with previously untreated, unresectable MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Eligible patients had an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 and no thrombosis, bleeding, or major blood vessel invasion. The primary end point was progression-free survival (PFS). Patients were stratified by ECOG performance status (0 v 1) and histologic subtype (epithelial v other). Patients received gemcitabine 1,250 mg\/m<jats:sup>2<\/jats:sup>on days 1 and 8 every 21 days, cisplatin 75 mg\/m<jats:sup>2<\/jats:sup>every 21 days, and bevacizumab 15 mg\/kg or placebo every 21 days for six cycles, and then bevacizumab or placebo every 21 days until progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifteen patients were enrolled at 11 sites; 108 patients were evaluable. Median PFS time was 6.9 months for the bevacizumab arm and 6.0 months for the placebo arm (P = .88). Median overall survival (OS) times were 15.6 and 14.7 months in the bevacizumab and placebo arms, respectively (P = .91). Partial response rates were similar (24.5% for bevacizumab v 21.8% for placebo; P = .74). A higher pretreatment plasma VEGF concentration (n = 56) was associated with shorter PFS (P = .02) and OS (P = .0066), independent of treatment arm. There were no statistically significant differences in toxicity of grade 3 or greater.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The addition of bevacizumab to gemcitabine\/cisplatin in this trial did not significantly improve PFS or OS in patients with advanced MM.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2011.41.5869","type":"journal-article","created":{"date-parts":[[2012,6,5]],"date-time":"2012-06-05T14:16:52Z","timestamp":1338905812000},"page":"2509-2515","source":"Crossref","is-referenced-by-count":154,"title":["Multicenter, Double-Blind, Placebo-Controlled, Randomized Phase II Trial of Gemcitabine\/Cisplatin Plus Bevacizumab or Placebo in Patients With Malignant Mesothelioma"],"prefix":"10.1200","volume":"30","author":[{"given":"Hedy L.","family":"Kindler","sequence":"first","affiliation":[{"name":"Hedy L. Kindler, Theodore G. Karrison, Samuel G. Armato III, Nicholas J. Vogelzang, Walter M. Stadler, and Everett E. Vokes, University of Chicago Comprehensive Cancer Center, Chicago; Kathy S. Albain, Loyola University, Maywood, IL; David R. Gandara, University of California at Davis, Sacramento; David I. Quinn, University of Southern California, Los Angeles; Marianna N. Koczywas, City of Hope Medical Center, Duarte, CA; Charles Lu, The University of Texas MD Anderson Cancer Center, Houston, TX; Lee M...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore G.","family":"Karrison","sequence":"additional","affiliation":[{"name":"Hedy L. Kindler, Theodore G. Karrison, Samuel G. Armato III, Nicholas J. Vogelzang, Walter M. Stadler, and Everett E. Vokes, University of Chicago Comprehensive Cancer Center, Chicago; Kathy S. Albain, Loyola University, Maywood, IL; David R. Gandara, University of California at Davis, Sacramento; David I. Quinn, University of Southern California, Los Angeles; Marianna N. Koczywas, City of Hope Medical Center, Duarte, CA; Charles Lu, The University of Texas MD Anderson Cancer Center, Houston, TX; Lee M...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Gandara","sequence":"additional","affiliation":[{"name":"Hedy L. Kindler, Theodore G. Karrison, Samuel G. Armato III, Nicholas J. Vogelzang, Walter M. Stadler, and Everett E. Vokes, University of Chicago Comprehensive Cancer Center, Chicago; Kathy S. Albain, Loyola University, Maywood, IL; David R. Gandara, University of California at Davis, Sacramento; David I. Quinn, University of Southern California, Los Angeles; Marianna N. Koczywas, City of Hope Medical Center, Duarte, CA; Charles Lu, The University of Texas MD Anderson Cancer Center, Houston, TX; Lee M...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Lu","sequence":"additional","affiliation":[{"name":"Hedy L. Kindler, Theodore G. Karrison, Samuel G. Armato III, Nicholas J. Vogelzang, Walter M. Stadler, and Everett E. Vokes, University of Chicago Comprehensive Cancer Center, Chicago; Kathy S. Albain, Loyola University, Maywood, IL; David R. Gandara, University of California at Davis, Sacramento; David I. Quinn, University of Southern California, Los Angeles; Marianna N. Koczywas, City of Hope Medical Center, Duarte, CA; Charles Lu, The University of Texas MD Anderson Cancer Center, Houston, TX; Lee M...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee M.","family":"Krug","sequence":"additional","affiliation":[{"name":"Hedy L. Kindler, Theodore G. Karrison, Samuel G. Armato III, Nicholas J. Vogelzang, Walter M. Stadler, and Everett E. Vokes, University of Chicago Comprehensive Cancer Center, Chicago; Kathy S. Albain, Loyola University, Maywood, IL; David R. Gandara, University of California at Davis, Sacramento; David I. Quinn, University of Southern California, Los Angeles; Marianna N. 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