{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:30:50Z","timestamp":1792074650015,"version":"4.4.0"},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p> A 42-year-old woman presented with bruising and fatigue. Her WBC count was 10,370\/\u03bcL, with a differential showing 5% polys, 5% monos, 10% lymphocytes, and 80% myeloid-appearing blasts, some of which contained Auer rods (Fig 1). Bone marrow examination revealed 90% infiltration with myeloid-appearing blasts, and flow cytometry analysis confirmed the diagnosis of acute myeloid leukemia (AML) with expression of CD33, CD13, and CD117. Cytogenetics revealed a normal female karyotype; molecular testing for NPM1, FLT3-ITD, and CEBP\u03b1mutations revealed wild-type status for each gene. The patient received induction therapy with daunorubicin 90 mg\/m<jats:sup>2<\/jats:sup> per day for 3 days and continuous-infusion cytarabine 100 mg\/m<jats:sup>2<\/jats:sup> per day for 7 days. After an induction course complicated by Gram-negative bacterial sepsis, her counts recovered by day 32, and bone marrow examination 6 weeks after diagnosis showed a complete remission. One week later she feels well and has normal physical and laboratory examinations. She is an only child (but has a common HLA type) and presents for discussion of postremission therapy options. <\/jats:p>","DOI":"10.1200\/jco.2012.43.4258","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T06:45:20Z","timestamp":1361861120000},"page":"1262-1266","source":"Crossref","is-referenced-by-count":23,"title":["Acute Myeloid Leukemia in First Remission: To Choose Transplantation or Not?"],"prefix":"10.1200","volume":"31","author":[{"given":"Richard M.","family":"Stone","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112304"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.13.4075"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235358"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-265603"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5977"},{"key":"B6","first-page":"2978","volume":"90","author":"Harousseau JL","year":"1997","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392301"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501263320403"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410063311402"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa074306"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21932"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-025627"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.813"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.9500"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.43.4258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:16:07Z","timestamp":1653520567000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.43.4258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,4,1]]}},"alternative-id":["10.1200\/JCO.2012.43.4258"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.43.4258","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}