{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T07:52:35Z","timestamp":1745308355959},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2012,12,10]]},"abstract":"<jats:p> A 52-year-old woman presents with a 2-month history of bright red blood per rectum. Her bleeding is associated with bowel movements and a sense of incomplete evacuation. She denies fecal incontinence or change in stool caliber. On digital rectal examination, the tumor is palpated approximately 3 cm from the anal verge, posterior and slightly to the right, positioned at the top of the anal canal and extending into the rectum, measuring approximately 2.5 cm. Additionally, a firm 1.5-cm left-sided inguinal node is palpated. The patient is then referred for colonoscopy, which reveals a mass in the anal canal; biopsy of the mass shows squamous cell carcinoma. Positron emission tomography\u2013computed tomography (PET-CT) demonstrates thickening in the low rectum with [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose (FDG) avidity ( Figs 1 A, 1 B). The left inguinal node is visualized, as is a perirectal lymph node with associated FDG avidity ( Figs 1 C, 1 D). The patient is staged as having T2N3 squamous cell carcinoma of the anal canal ( Table 1 ). Her medical history is otherwise unremarkable, including for HIV, prior abnormal Papanicolaou smears, and other risk factors for human papillomavirus (HPV) exposure. <\/jats:p>","DOI":"10.1200\/jco.2012.44.8878","type":"journal-article","created":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T01:59:30Z","timestamp":1352858370000},"page":"4297-4301","source":"Crossref","is-referenced-by-count":7,"title":["Mitomycin in Anal Cancer: Still the Standard of Care"],"prefix":"10.1200","volume":"30","author":[{"given":"Joanna Y.","family":"Chin","sequence":"first","affiliation":[{"name":"Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore S.","family":"Hong","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9125-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.10.048"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830515)51:10<1826::AID-CNCR2820511012>3.0.CO;2-L"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03409-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.5.2040"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2527"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011107105538"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.2339"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.16.1914"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.8085"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.29.1351"},{"key":"B12","first-page":"30","author":"Glynne-Jones R","year":"2012","journal-title":"J Clin Oncol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.030"},{"key":"B14","first-page":"29","author":"Kachnic LA","year":"2011","journal-title":"J Clin Oncol"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.44.8878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:11:56Z","timestamp":1653520316000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.44.8878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,10]]},"references-count":14,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2012,12,10]]}},"alternative-id":["10.1200\/JCO.2012.44.8878"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.44.8878","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,10]]}}}