{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:00Z","timestamp":1792098420350,"version":"4.4.0"},"reference-count":46,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,11,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Open-label, phase III trial evaluating whether sunitinib was superior or equivalent to sorafenib in hepatocellular cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients were stratified and randomly assigned to receive sunitinib 37.5 mg once per day or sorafenib 400 mg twice per day. Primary end point was overall survival (OS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Early trial termination occurred for futility and safety reasons. A total of 1,074 patients were randomly assigned to the study (sunitinib arm, n = 530; sorafenib arm, n = 544). For sunitinib and sorafenib, respectively, median OS was 7.9 versus 10.2 months (hazard ratio [HR], 1.30; one-sided P = .9990; two-sided P = .0014); median progression-free survival (PFS; 3.6 v 3.0 months; HR, 1.13; one-sided P = .8785; two-sided P = .2286) and time to progression (TTP; 4.1 v 3.8 months; HR, 1.13; one-sided P = .8312; two-sided P = .3082) were comparable. Median OS was similar among Asian (7.7 v 8.8 months; HR, 1.21; one-sided P = .9829) and hepatitis B\u2013infected patients (7.6 v 8.0 months; HR, 1.10; one-sided P = .8286), but was shorter with sunitinib in hepatitis C\u2013infected patients (9.2 v 17.6 months; HR, 1.52; one-sided P = .9835). Sunitinib was associated with more frequent and severe adverse events (AEs) than sorafenib. Common grade 3\/4 AEs were thrombocytopenia (29.7%) and neutropenia (25.7%) for sunitinib; hand-foot syndrome (21.2%) for sorafenib. Discontinuations owing to AEs were similar (sunitinib, 13.3%; sorafenib, 12.7%). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> OS with sunitinib was not superior or equivalent but was significantly inferior to sorafenib. OS was comparable in Asian and hepatitis B\u2013infected patients. OS was superior in hepatitis C\u2013infected patients who received sorafenib. Sunitinib-treated patients reported more frequent and severe toxicity. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2012.45.8372","type":"journal-article","created":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T07:15:35Z","timestamp":1380611735000},"page":"4067-4075","source":"Crossref","is-referenced-by-count":647,"title":["Sunitinib Versus Sorafenib in Advanced Hepatocellular Cancer: Results of a Randomized Phase III Trial"],"prefix":"10.1200","volume":"31","author":[{"given":"Ann-Lii","family":"Cheng","sequence":"first","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Koo","family":"Kang","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng-Yn","family":"Lin","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joong-Won","family":"Park","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukui","family":"Qin","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Cheol","family":"Chung","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqun","family":"Song","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Xu","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Poggi","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Omata","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Pitman Lowenthal","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Lanzalone","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Lechuga","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Raymond","sequence":"additional","affiliation":[{"name":"Ann-Lii Cheng, National Taiwan University Hospital, Taipei; Deng-Yn Lin, Chang Gung Memorial Hospital, Chang Gung University, Guishan Township, Taiwan, Republic of China; Yoon-Koo Kang, Asan Medical Center, University of Ulsan College of Medicine; Hyun-Cheol Chung, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul; Joong-Won Park, National Cancer Center, Goyang, Republic of Korea; Masatoshi Kudo, Kinki University Hospital, Osaka; Masao Omata, Yamanashi Prefecture Central Hospital, Kofu,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"B4","first-page":"291","volume":"9","author":"Smedile A","year":"2005","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.089"},{"key":"B6","first-page":"220","volume":"4","author":"Yao DF","year":"2005","journal-title":"HepatobiliaryPancreat Dis Int"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i26.4241"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.17.4762"},{"key":"B9","first-page":"327","volume":"9","author":"Mendel DB","year":"2003","journal-title":"Clin Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1023\/B:CLIN.0000006873.65590.68"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2307"},{"key":"B12","first-page":"471","volume":"2","author":"Abrams TJ","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2845"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2903"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2380"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70171-8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.9908"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0316"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007122"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0708857"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2307\/2530245"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2307\/2336502"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.8711"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5628"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.29.15_suppl.4000"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70285-7"},{"key":"B28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/1471-2407-8-349","volume":"8","author":"Hoffman K","year":"2008","journal-title":"BMC Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.06.014"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270409"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6840"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.4.1736-1741.2000"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204372"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.12.071"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.08.018"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.182212"},{"key":"B37","first-page":"7099","volume":"64","author":"Wilhelm SM","year":"2004","journal-title":"Clin Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.04.007"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.047"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1033"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn134"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70222-0"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003825"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5476"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.02.011"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.45.8372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:58:48Z","timestamp":1653519528000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.45.8372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,10]]},"references-count":46,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2013,11,10]]}},"alternative-id":["10.1200\/JCO.2012.45.8372"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.45.8372","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,10]]}}}