{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:35:56Z","timestamp":1762781756314},"reference-count":59,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,4,10]]},"abstract":"<jats:p> A 56-year-old postmenopausal woman with a recent diagnosis of breast cancer was referred to discuss adjuvant therapy. Annual screening mammogram demonstrated a suspicious mass in the left breast. Ultrasound-guided core needle biopsy revealed an infiltrating ductal carcinoma that was estrogen receptor (ER) positive and progesterone receptor (PR) negative and lacked amplification of human epidermal growth factor receptor 2 (HER2; ie, HER2 negative). She underwent excision and sentinel node evaluation. Pathology demonstrated a 1.9-cm grade 2 invasive cancer without lymphatic vascular invasion; clean margins were obtained, and both sentinel nodes were free of cancer. The 21-gene recurrence score was 16. She has a body mass index (BMI) of 28.5 but is otherwise healthy; levothyroxine is the only prescription medication she takes. She experienced vaginal spotting 2 years earlier because of an endometrial polyp, which was resected. She exercises regularly and takes a calcium supplement with vitamin D. Bone density study performed 6 months earlier was normal other than mild osteopenia in the femoral neck (T score, \u22121.3). Radiation therapy is planned <\/jats:p>","DOI":"10.1200\/jco.2012.46.6599","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T02:38:42Z","timestamp":1359427122000},"page":"1391-1397","source":"Crossref","is-referenced-by-count":13,"title":["What Is the Optimal Endocrine Therapy for Postmenopausal Women With Hormone Receptor\u2013Positive Early Breast Cancer?"],"prefix":"10.1200","volume":"31","author":[{"given":"Nadine","family":"Tung","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020299707510"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60993-8"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.1274"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810818"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70270-4"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62312-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji250"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.4010"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.0228"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm246"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3756"},{"key":"B14","first-page":"1736","volume":"22","author":"Goldhirsch A","year":"2011","journal-title":"Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer. Ann Oncol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70257-6"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.7899"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.120"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl941"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.8054"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.8993"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6798"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09088-8"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17666-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70385-6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052258"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.6455"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.9437"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9453"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.3677"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.4798"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.0829"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm001"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq738"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.2021"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.2585"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.0273"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs126"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs125"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.8931"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.7906"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23171"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.18.1371"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr242"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji372"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060508"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.0726"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0261"},{"key":"B48","first-page":"1401","volume":"22","author":"Henry NL","year":"2008","journal-title":"Oncology (Williston Park)"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.2933"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103507"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.SABCS12-S1-2"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.751"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.9279"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.6950"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7805"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1132-4"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604758"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3744"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23259"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.3832"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.46.6599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:13:38Z","timestamp":1653520418000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.46.6599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,4,10]]}},"alternative-id":["10.1200\/JCO.2012.46.6599"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.46.6599","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]}}}