{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:12:44Z","timestamp":1792872764277,"version":"4.5.0"},"reference-count":65,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some gene mutations\u2014including ASXL1\u2014have been associated with poor prognosis in univariable analyses. We developed and validated a prognostic score for overall survival (OS) based on mutational status and standard clinical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We genotyped ASXL1 and up to 18 other genes including epigenetic (TET2, EZH2, IDH1, IDH2, DNMT3A), splicing (SF3B1, SRSF2, ZRSF2, U2AF1), transcription (RUNX1, NPM1, TP53), and signaling (NRAS, KRAS, CBL, JAK2, FLT3) regulators in 312 patients with CMML. Genotypes and clinical variables were included in a multivariable Cox model of OS validated by bootstrapping. A scoring system was developed using regression coefficients from this model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ASXL1 mutations (P &lt; .0001) and, to a lesser extent, SRSF2 (P = .03), CBL (P = .003), and IDH2 (P = .03) mutations predicted inferior OS in univariable analysis. The retained independent prognostic factors included ASXL1 mutations, age older than 65 years, WBC count greater than 15 \u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L, platelet count less than 100 \u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L, and anemia (hemoglobin &lt; 10 g\/dL in female patients, &lt; 11g\/dL in male patients). The resulting five-parameter prognostic score delineated three groups of patients with median OS not reached, 38.5 months, and 14.4 months, respectively (P &lt; .0001), and was validated in an independent cohort of 165 patients (P &lt; .0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A new prognostic score including ASXL1 status, age, hemoglobin, WBC, and platelet counts defines three groups of CMML patients with distinct outcomes. Based on concordance analysis, this score appears more discriminative than those based solely on clinical parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2012.47.3314","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T01:07:52Z","timestamp":1369098472000},"page":"2428-2436","source":"Crossref","is-referenced-by-count":501,"title":["Prognostic Score Including Gene Mutations in Chronic Myelomonocytic Leukemia"],"prefix":"10.1200","volume":"31","author":[{"given":"Rapha\u00ebl","family":"Itzykson","sequence":"first","affiliation":[{"name":"Rapha\u00ebl Itzykson, Margot Morabito, Olivier A. Bernard, William Vainchenker, Nathalie Droin, Eric Solary, Institut Gustave Roussy, Villejuif; Rapha\u00ebl Itzykson, Margot Morabito, William Vainchenker, Nathalie Droin, Eric Solary, Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, Orsay; Olivier Kosmider, Fran\u00e7ois Dreyfus, Michaela Fontenay, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Cochin; Olivier Kosmider, Fran\u00e7ois Dreyfus, Michaela Fontenay, Universit\u00e9 Paris Descartes; Olivier Kosmider, Michaela Fontenay,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Kosmider","sequence":"additional","affiliation":[{"name":"Rapha\u00ebl Itzykson, Margot Morabito, Olivier A. Bernard, William Vainchenker, Nathalie Droin, Eric Solary, Institut Gustave Roussy, Villejuif; Rapha\u00ebl Itzykson, Margot Morabito, William Vainchenker, Nathalie Droin, Eric Solary, Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, Orsay; Olivier Kosmider, Fran\u00e7ois Dreyfus, Michaela Fontenay, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Cochin; Olivier Kosmider, Fran\u00e7ois Dreyfus, Michaela Fontenay, Universit\u00e9 Paris Descartes; Olivier Kosmider, Michaela Fontenay,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Renneville","sequence":"additional","affiliation":[{"name":"Rapha\u00ebl Itzykson, Margot Morabito, Olivier A. 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