{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:30:32Z","timestamp":1791174632618,"version":"4.1.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and\/or FBXW7 (N\/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N\/F-mutated T-ALL experienced relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In a series of 212 adult T-ALLs included in the multicenter randomized GRAALL-2003 and -2005 trials, we searched for additional N\/K-RAS mutations and PTEN defects (mutations and gene deletion).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>N\/F mutations were identified in 143 (67%) of 212 patients, and lack of N\/F mutation was confirmed to be associated with a poor prognosis. K-RAS, N-RAS, and PTEN mutations\/deletions were identified in three (1.6%) of 191, 17 (8.9%) of 191, and 21 (12%) of 175 patients, respectively. The favorable prognostic significance of N\/F mutations was restricted to patients without RAS\/PTEN abnormalities. These observations led us to propose a new T-ALL oncogenetic classifier defining low-risk patients as those with N\/F mutation but no RAS\/PTEN mutation (97 of 189 patients; 51%) and all other patients (49%; including 13% with N\/F and RAS\/PTEN mutations) as high-risk patients. In multivariable analysis, this oncogenetic classifier remained the only significant prognostic covariate (event-free survival: hazard ratio [HR], 3.2; 95% CI, 1.9 to 5.15; P &lt; .001; and overall survival: HR, 3.2; 95% CI, 1.9 to 5.6; P &lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data demonstrate that the presence of N\/F mutations in the absence of RAS or PTEN abnormalities predicts good outcome in almost 50% of adult T-ALL. Conversely, the absence of N\/F or presence of RAS\/PTEN alterations identifies the remaining cohort of patients with poor prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2012.48.5292","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T22:13:11Z","timestamp":1382998391000},"page":"4333-4342","source":"Crossref","is-referenced-by-count":236,"title":["Toward a\n                    <i>NOTCH1\/FBXW7\/RAS\/PTEN<\/i>\n                    \u2013Based Oncogenetic Risk Classification of Adult T-Cell Acute Lymphoblastic Leukemia: A Group for Research in Adult Acute Lymphoblastic Leukemia Study"],"prefix":"10.1200","volume":"31","author":[{"given":"Am\u00e9lie","family":"Trinquand","sequence":"first","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Tanguy-Schmidt","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raouf","family":"Ben Abdelali","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Lambert","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kheira","family":"Beldjord","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Lenglin\u00e9","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"De Gunzburg","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Payet-Bornet","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Lhermitte","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Mossafa","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lh\u00e9ritier","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bond","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Huguet","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Buzyn","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Leguay","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Cahn","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Thomas","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Delannoy","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Bonmati","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Maury","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Nadel","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Macintyre","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Ifrah","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Asnafi","sequence":"additional","affiliation":[{"name":"Am\u00e9lie Trinquand, Raouf Ben Abdelali, Etienne Lenglin\u00e9, No\u00e9mie De Gunzburg, Ludovic Lhermitte, Jonathan Bond, Agn\u00e8s Buzyn, Elizabeth Macintyre, and Vahid Asnafi, University Paris Descartes, Centre National de la Recherche Scientifique (CNRS) Unit\u00e9 Mixte de Recherche (UMR)-8147, and Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Necker-Enfants Malades; J\u00e9r\u00f4me Lambert, UMR-S-717, H\u00f4pital Saint-Louis, AP-HP; Kheira Beldjord, Etienne Lenglin\u00e9, and Herv\u00e9 Dombret, University Paris 7, H\u00f4pital Saint..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052603"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2304"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334219"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2508"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00018-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-3900"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61269"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102160"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070876"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1623"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.7"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.6916"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-336842"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-02-206722"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"B17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox D","year":"1972","journal-title":"J R Stat Soc B"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/92.4.965"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-184069"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07314.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.467"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(01)00234-0"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3330"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nature06933"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.073585"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.059030"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-009498"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134262"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403272"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112239"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-11-3944"},{"key":"B32","first-page":"1406","volume":"8","author":"Digel W","year":"1994","journal-title":"Leukemia"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.5.1247.1247"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.48.5292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T19:51:22Z","timestamp":1716061882000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.48.5292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,1]]},"references-count":33,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2013,12,1]]}},"alternative-id":["10.1200\/JCO.2012.48.5292"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.48.5292","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718156943.793495862","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,1]]}}}