{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:35:30Z","timestamp":1792100130997,"version":"4.4.0"},"reference-count":14,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,2,10]]},"abstract":"Purpose<\/jats:title> More than half of patients with chronic-phase chronic myelogenous leukemia (CP-CML) in complete molecular response (CMR) experience molecular relapse after imatinib discontinuation. We investigated loss of major molecular response (MMR) as a criterion for resuming therapy. <\/jats:p><\/jats:sec>Patients and Methods<\/jats:title> A multicenter observational study (A-STIM [According to Stop Imatinib]) evaluating MMR persistence was conducted in 80 patients with CP-CML who had stopped imatinib after prolonged CMR. <\/jats:p><\/jats:sec>Results<\/jats:title> Median time from imatinib initiation to discontinuation was 79 months (range, 30 to 145 months);median duration of CMR before imatinib discontinuation was 41 months (range, 24 to 96 months); median follow-up after discontinuation was 31 months (range, 8 to 92 months). Twenty-nine patients (36%) lost MMR after a median of 4 months off therapy (range, 2 to 17 months). Cumulative incidence of MMR loss was estimated as 35% (95% CI, 25% to 46%) at 12 months and 36% (95% CI, 26% to 47%) at 24 months, whereas probability of losing CMR was higher. Fluctuation of BCR-ABL transcript levels below the MMR threshold (\u2265 two consecutive positive values) was observed in 31% of patients after imatinib discontinuation. Treatment-free remission was estimated as 64% (95% CI, 54% to 75%) at 12 and 24 months and 61% (95% CI, 51% to 73%) at 36 months. Median to time to second CMR was estimated as 7.3 months in re-treated patients. <\/jats:p><\/jats:sec>Conclusion<\/jats:title> Loss of MMR is a practical and safe criterion for restarting therapy in patients with CML with prolonged CMR. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2012.48.5797","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T05:11:39Z","timestamp":1386652299000},"page":"424-430","source":"Crossref","is-referenced-by-count":380,"title":["Loss of Major Molecular Response As a Trigger for Restarting Tyrosine Kinase Inhibitor Therapy in Patients With Chronic-Phase Chronic Myelogenous Leukemia Who Have Stopped Imatinib After Durable Undetectable Disease"],"prefix":"10.1200","volume":"32","author":[{"given":"Philippe","family":"Rousselot","sequence":"first","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Charbonnier","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cony-Makhoul","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Agape","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck E.","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Varet","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Gardembas","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Etienne","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"R\u00e9a","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Roy","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Escoffre-Barbe","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Guerci-Bresler","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Tulliez","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Prost","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Spentchian","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Michel","family":"Cayuela","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josy","family":"Reiffers","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Chomel","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Turhan","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Guilhot","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guilhot","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Xavier","family":"Mahon","sequence":"additional","affiliation":[{"name":"Philippe Rousselot, H\u00f4pital Mignot, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles; Aude Charbonnier, Institut Paoli Calmette, Marseille; Pascale Cony-Makhoul, H\u00f4pital d'Annecy, Pringy; Philippe Agape, H\u00f4pital Felix Guyon\u2013Centre Hospitalier Universitaire en France (CHU) de la R\u00e9union, La R\u00e9union; Franck E. Nicolini, Centre Hospitalier Lyon Sud, Pierre-B\u00e9nite; Bruno Varet, H\u00f4pital Necker, Assistance Publique\u2013Hopitaux de Paris (AP-HP) et Universit\u00e9 Paris Descartes; Delphine R\u00e9a and Jean Michel..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-011239"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70233-3"},{"key":"B3","first-page":"118","author":"Mahon FX","year":"2011","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-483750"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.056853"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2012.02.011"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404983"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-335497"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1010"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22046"},{"key":"B11","first-page":"118","author":"Milojkovic D","year":"2011","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.104"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.1.214"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3320"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.48.5797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:50:05Z","timestamp":1653519005000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.48.5797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,2,10]]}},"alternative-id":["10.1200\/JCO.2012.48.5797"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.48.5797","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]}}}