{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:49:39Z","timestamp":1792712979991,"version":"4.5.0"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,2,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Kaposi's sarcoma (KS) is a disease of multifocal vascular proliferation that requires infection with KS herpes virus (KSHV\/HHV-8). Activation of the c-kit and platelet-derived growth factor (PDGF) receptors by autocrine\/paracrine mechanisms follows endothelial cell KSHV infection. In a pilot study, imatinib, a c-kit\/PDGF-receptor inhibitor, induced partial regression of AIDS-associated KS (AIDS-KS) in five of 10 patients. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> This multicenter phase II study was designed to estimate the response rate to imatinib in AIDS-KS. Secondary objectives included investigation of predictors of response and imatinib pharmacokinetics in patients on antiretrovirals. Patients received imatinib 400 mg\/day by mouth for up to 12 months with dose escalation up to 600 mg\/day at 3 months if their disease was stable. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Thirty patients were treated at 12 AIDS Malignancy Consortium sites. Ten patients (33.3%) achieved partial response, six (20%) had stable disease, and seven (23.3%) exhibited KS progression. Nine patients completed 52 weeks of imatinib therapy. The median treatment duration was 22.5 weeks. Only five patients (16.7%) discontinued therapy owing to adverse events. Antiretroviral regimens did not significantly alter imatinib metabolism. Activating mutations in PDGF-R and c-kit were not found at baseline or at disease progression. We found no correlation with response with changes in any of the candidate cytokines. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Imatinib has activity in AIDS-KS. Pharmacokinetic interactions with antiretroviral drugs did not correlate with toxicity. Thirty percent of patients showed long-term clinical benefit and remained on imatinib for the entire year. These results suggest imatinib is well tolerated and may be an alternative therapy for some patients with AIDS-KS. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2012.48.6365","type":"journal-article","created":{"date-parts":[[2013,12,31]],"date-time":"2013-12-31T02:44:44Z","timestamp":1388457884000},"page":"402-408","source":"Crossref","is-referenced-by-count":94,"title":["Phase II Trial of Imatinib in AIDS-Associated Kaposi's Sarcoma: AIDS Malignancy Consortium Protocol 042"],"prefix":"10.1200","volume":"32","author":[{"given":"Henry B.","family":"Koon","sequence":"first","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Krown","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kord","family":"Honda","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthee","family":"Rapisuwon","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghe","family":"Wang","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aboulafia","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin G.","family":"Reid","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Rudek","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Dezube","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela","family":"Noy","sequence":"additional","affiliation":[{"name":"Henry B. Koon and Zhenghe Wang, Case Comprehensive Cancer Center, Case Western Reserve University; Kord Honda, University Hospitals; Cleveland, OH; Susan E. Krown, Ariela Noy, Memorial Sloan-Kettering Cancer Center, New York, NY; Jeannette Y. Lee, University of Arkansas for Medical Sciences, Little Rock, AR; Suthee Rapisuwon, Georgetown University Medical Center, Washington, DC; David Aboulafia, Virginia Mason Medical Center, Seattle, WA; Erin G. Reid, University of California San Diego Moores Cancer..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-707"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2643161"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.3.979"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4068"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199210000-00010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.7046"},{"key":"B7","first-page":"1851","volume":"149","author":"Cornali E","year":"1996","journal-title":"Am J Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.16.8383-8399.2002"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.1928"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.01.027"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.079"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051140"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00206-X"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-008-0778-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2008.10.002"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90015-9"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.11.043"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2002.20.1.153"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116475"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0422"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M700596-MCP200"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2012.48.6365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:49:58Z","timestamp":1653518998000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2012.48.6365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,2,10]]}},"alternative-id":["10.1200\/JCO.2012.48.6365"],"URL":"https:\/\/doi.org\/10.1200\/jco.2012.48.6365","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]}}}