{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:47:12Z","timestamp":1791726432828,"version":"4.3.4"},"reference-count":45,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,7,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To gain insight into the prevalence and severity of chemotherapy-induced neuropathy and its influence on health-related quality of life (HRQOL) in a population-based sample of colorectal cancer (CRC) survivors 2 to 11 years after diagnosis. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> All alive individuals diagnosed with CRC between 2000 and 2009 as registered by the Dutch population-based Eindhoven Cancer Registry were eligible for participation. Eighty-three percent (n = 1,643) of patients filled out the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) C30 and the EORTC QLQ Chemotherapy-Induced Peripheral Neuropathy 20. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The five neuropathy subscale\u2013related symptoms that bothered patients with CRC the most during the past week were erectile problems (42% of men), trouble hearing (11%), trouble opening jars or bottles (11%), tingling toes\/feet (10%), and trouble walking stairs or standing up (9%). Additionally, patients who received oxaliplatin more often reported tingling (29% v 8%; P = .001), numbness (17% v 5%; P = .005), and aching or burning pain (13% v 6%; P = .03) in toes\/feet compared with those not treated with chemotherapy. They also more often reported tingling toes\/feet (29% v 14%; P = .0127) compared with those treated with chemotherapy without oxaliplatin. Those with many neuropathy symptoms (eg, upper 10%) reported statistically significant and clinically relevant worse HRQOL scores on all EORTC QLQ-C30 subscales (all P &lt; .01). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Two to 11 years after diagnosis of CRC, neuropathy-related symptoms are still reported, especially sensory symptoms in the lower extremities among those treated with oxaliplatin. Because neuropathy symptoms have a negative influence on HRQOL, these should be screened for and alleviated. Future studies should focus on prevention and relief of chemotherapy-induced neuropathy. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.49.1514","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T03:54:47Z","timestamp":1371527687000},"page":"2699-2707","source":"Crossref","is-referenced-by-count":318,"title":["Chemotherapy-Induced Neuropathy and Its Association With Quality of Life Among 2- to 11-Year Colorectal Cancer Survivors: Results From the Population-Based PROFILES Registry"],"prefix":"10.1200","volume":"31","author":[{"given":"Floortje","family":"Mols","sequence":"first","affiliation":[{"name":"Floortje Mols and Lonneke van de Poll-Franse, Center of Research on Psychology in Somatic Diseases, Tilburg University, Tilburg; Floortje Mols, Valery Lemmens, Corina van den Hurk, and Lonneke van de Poll-Franse, Comprehensive Cancer Centre South, Eindhoven Cancer Registry, Eindhoven; Tonneke Beijers and Gerard Vreugdenhil, Maxima Medical Centre, 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