{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:15:12Z","timestamp":1790162112351,"version":"4.1.0"},"reference-count":29,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,1,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> We report an international, multicenter phase II trial to evaluate the efficacy and toxicity of fractionated <jats:sup>90<\/jats:sup>Y-ibritumomab tiuxetan (<jats:sup>90<\/jats:sup>Y-IT) as initial therapy of follicular lymphoma (FL). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> A total of 74 patients, with a median age of 61 years (range, 28 to 80 years), were recruited requiring initial therapy by Groupe d'Etude des Lymphomes Folliculaires (GELF)\/British National Lymphoma Investigation (BNLI) criteria. Among them, 78% had stage III-IV disease, 32% intermediate, and 44% high-risk (according to FL International Prognostic Index). Treatment consisted of two doses of <jats:sup>90<\/jats:sup>Y-IT (11.1 MBq\/kg) administered 8 to 12 weeks apart. Patients with more than 20% lymphoma infiltration of bone marrow (BM) received one infusion per week for 4 consecutive weeks of rituximab (375 mg\/m<jats:sup>2<\/jats:sup>) and proceeded to fractionated radioimmunotherapy (RIT) only if a repeat BM biopsy demonstrated clearing of lymphoma to less than 20% involvement. The primary end point was end of treatment response of the intention-to-treat population. Secondary objectives were safety and progression-free survival (PFS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Initial overall response rate (ORR) was 94.4% (68 of 72 patients) with combined complete response (CR\/CRu) of 58.3% (42 of 72 patients). Nine patients subsequently improved response making an ORR of 95.8% (69 of 72 patients) and CR\/CRu of 69.4% (50 of 72 patients). At a median follow-up of 3.1 years (range, 0.2 to 5.2 years) estimated 3-year PFS is 58%, treatment-free survival 66%, and overall survival 95%. Median PFS is 40.2 months. Thirty patients have experienced disease progression and 24 have required further treatment. The treatment was well tolerated with few (2.8%) grade 3 or 4 infectious episodes or adverse events and manageable hematologic toxicity. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Fractionated RIT using <jats:sup>90<\/jats:sup>Y-IT is an effective initial treatment for advanced-stage FL in patients with higher tumor burden requiring treatment. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.50.3110","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T05:09:54Z","timestamp":1386047394000},"page":"212-218","source":"Crossref","is-referenced-by-count":55,"title":["Fractionated <sup>90<\/sup>Y-Ibritumomab Tiuxetan Radioimmunotherapy As an Initial Therapy of Follicular Lymphoma: An International Phase II Study in Patients Requiring Treatment According to GELF\/BNLI Criteria"],"prefix":"10.1200","volume":"32","author":[{"given":"Tim M.","family":"Illidge","sequence":"first","affiliation":[{"name":"Tim M. Illidge, Sam Mayes, John A. Radford, W. David J. Ryder, Manchester Academic Health Science Centre, University of Manchester; Jill Tipping, Maureen Zivanovic, Christie Hospital NHS Foundation Trust, Manchester; Ruth Pettengell, St. George's, University of London, London; Andrew T. Bates, Southampton University Hospitals NHS Foundation Trust, Southampton; Mike Bayne, Poole Hospital NHS Foundation Trust, Dorset, United Kingdom; Steven Le Gouill, Centre Hospitalier Universitaire Nantes; Fran\u00e7oise..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Mayes","sequence":"additional","affiliation":[{"name":"Tim M. Illidge, Sam Mayes, John A. Radford, W. David J. Ryder, Manchester Academic Health Science Centre, University of Manchester; Jill Tipping, Maureen Zivanovic, Christie Hospital NHS Foundation Trust, Manchester; Ruth Pettengell, St. George's, University of London, London; Andrew T. Bates, Southampton University Hospitals NHS Foundation Trust, Southampton; Mike Bayne, Poole Hospital NHS Foundation Trust, Dorset, United Kingdom; Steven Le Gouill, Centre Hospitalier Universitaire Nantes; Fran\u00e7oise..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Pettengell","sequence":"additional","affiliation":[{"name":"Tim M. Illidge, Sam Mayes, John A. Radford, W. David J. Ryder, Manchester Academic Health Science Centre, University of Manchester; Jill Tipping, Maureen Zivanovic, Christie Hospital NHS Foundation Trust, Manchester; Ruth Pettengell, St. George's, University of London, London; Andrew T. 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