{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:21:48Z","timestamp":1792844508358,"version":"4.5.0"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"33","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2013,11,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To investigate the prognostic value of the Hematopoietic Cell Transplantation\u2013Specific Comorbidity Index (HCT-CI) in patients who received transplantation admitted to the intensive care unit (ICU). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We investigated the association of HCT-CI with inpatient mortality and overall survival (OS) among 377 patients who were admitted to the ICU within 100 days of allogeneic stem-cell transplantation (ASCT) at our institution. HCT-CI scores were collapsed into four groups and were evaluated in univariate and multivariate analyses using logistic regression and Cox proportional hazards models. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The most common pretransplantation comorbidities were pulmonary and cardiac diseases, and respiratory failure was the primary reason for ICU admission. We observed a strong trend for higher inpatient mortality and shorter OS among patients with HCT-CI values \u2265 2 compared with patients with values of 0 to 1 in all patient subsets studied. Multivariate analysis showed that patients with HCT-CI values \u2265 2 had significantly higher inpatient mortality than patients with values of 0 to 1 and that HCT-CI values \u2265 4 were significantly associated with shorter OS compared with values of 0 to 1 (hazard ratio, 1.74; 95% CI, 1.23 to 2.47). The factors associated with lower inpatient mortality were ICU admission during the ASCT conditioning phase or the use of reduced-intensity conditioning regimens. The overall inpatient mortality rate was 64%, and the 1-year OS rate was 15%. Among patients with HCT-CI scores of 0 to 1, 2, 3, and \u2265 4, the 1-year OS rates were 22%, 17%, 18%, and 9%, respectively. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> HCT-CI is a valuable predictor of mortality and survival in critically ill patients after ASCT. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.50.5867","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T00:51:05Z","timestamp":1381798265000},"page":"4207-4214","source":"Crossref","is-referenced-by-count":80,"title":["Hematopoietic Cell Transplantation\u2013Specific Comorbidity Index Predicts Inpatient Mortality and Survival in Patients Who Received Allogeneic Transplantation Admitted to the Intensive Care Unit"],"prefix":"10.1200","volume":"31","author":[{"given":"Ulas D.","family":"Bayraktar","sequence":"first","affiliation":[{"name":"All authors: The University of Texas MD Anderson Cancer Center, Houston, 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