{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:05:54Z","timestamp":1791558354104,"version":"4.3.4"},"reference-count":13,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the effects of bevacizumab on patient-reported outcomes (PROs; secondary end point) in the AURELIA trial. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients with platinum-resistant ovarian cancer were randomly assigned to chemotherapy alone (CT) or with bevacizumab (BEV-CT). PROs were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire\u2013Ovarian Cancer Module 28 (EORTC QLQ-OV28) and Functional Assessment of Cancer Therapy\u2013Ovarian Cancer symptom index (FOSI) at baseline and every two or three cycles (8\/9 weeks) until disease progression. The primary PRO hypothesis was that more patients receiving BEV-CT than CT would achieve at least a 15% (\u2265 15-point) absolute improvement on the QLQ-OV28 abdominal\/GI symptom subscale (items 31-36) at week 8\/9. Patients with missing week 8\/9 questionnaires were included as unimproved. Questionnaires from all assessments until disease progression were analyzed using mixed-model repeated-measures (MMRM) analysis. Sensitivity analyses were used to determine the effects of differing assumptions and methods for missing data. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Baseline questionnaires were available from 89% of 361 randomly assigned patients. More BEV-CT than CT patients achieved a \u2265 15% improvement in abdominal\/GI symptoms at week 8\/9 (primary PRO end point, 21.9% v 9.3%; difference, 12.7%; 95% CI, 4.4 to 20.9; P = .002). MMRM analysis covering all time points also favored BEV-CT (difference, 6.4 points; 95% CI, 1.3 to 11.6; P = .015). More BEV-CT than CT patients achieved \u2265 15% improvement in FOSI at week 8\/9 (12.2% v 3.1%; difference, 9.0%; 95% CI, 2.9% to 15.2%; P = .003). Sensitivity analyses gave similar results and conclusions. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Bevacizumab increased the proportion of patients achieving a 15% improvement in patient-reported abdominal\/GI symptoms during chemotherapy for platinum-resistant ovarian cancer. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.51.4240","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T06:15:08Z","timestamp":1396332908000},"page":"1309-1316","source":"Crossref","is-referenced-by-count":152,"title":["Patient-Reported Outcome Results From the Open-Label Phase III AURELIA Trial Evaluating Bevacizumab-Containing Therapy for Platinum-Resistant Ovarian Cancer"],"prefix":"10.1200","volume":"32","author":[{"given":"Martin R.","family":"Stockler","sequence":"first","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Hilpert","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine T.","family":"King","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lari","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Khoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Joly","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"de Gregorio","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Angel","family":"Arranz","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor Raza","family":"Mirza","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sorio","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Freudensprung","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Sneller","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Hales","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pujade-Lauraine","sequence":"additional","affiliation":[{"name":"Martin R. Stockler, Madeleine T. King, Chee Khoon Lee, The University of Sydney; Michael Friedlander, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; Felix Hilpert, Arbeitsgemeinschaft Gyn\u00e4kologische Onkologie (AGO) and Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Kiel; Nikolaus de Gregorio, AGO and University of Ulm Medical Center, Ulm, Germany; Lari Wenzel, University of California Irvine, Irvine, CA; Florence Joly, Group d'Investigateurs Nationaux pour l'Etude des..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2165\/11591720-000000000-00000"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181bf7fb8"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.4489"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e31821bb8aa"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00307-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.25.18_suppl.16021"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e3181dad379"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-120022366"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.017"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.4645"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2007.00273.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/10543401003777995"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2013.51.4240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T23:04:52Z","timestamp":1653519892000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2013.51.4240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,1]]},"references-count":13,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2014,5,1]]}},"alternative-id":["10.1200\/JCO.2013.51.4240"],"URL":"https:\/\/doi.org\/10.1200\/jco.2013.51.4240","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,1]]}}}