{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:36:41Z","timestamp":1793036201775,"version":"4.5.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,4,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas (PTCLs) and is associated with poor outcomes. Mogamulizumab (KW-0761) is a defucosylated humanized anti-CCR4 antibody engineered to exert potent antibody-dependent cellular cytotoxicity. This multicenter phase II study evaluated the efficacy and safety of mogamulizumab in patients with relapsed PTCL and cutaneous T-cell lymphoma (CTCL). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Mogamulizumab (1.0 mg\/kg) was administered intravenously once per week for 8 weeks to patients with relapsed CCR4-positive PTCL or CTCL. The primary end point was the overall response rate, and the secondary end points included safety, progression-free survival (PFS), and overall survival (OS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> A total of 38 patients were enrolled, and 37 patients received mogamulizumab. Objective responses were noted for 13 of 37 patients (35%; 95% CI, 20% to 53%), including five patients (14%) with complete response. The median PFS was 3.0 months (95% CI, 1.6 to 4.9 months), and the median OS was not calculated. The mean maximum and trough mogamulizumab concentrations (\u00b1 standard deviation) after the eighth infusion were 45.9 \u00b1 9.3 and 29.0 \u00b1 13.3 \u03bcg\/mL, respectively. The most common adverse events were hematologic events, pyrexia, and skin disorders, all of which were reversible and manageable. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Mogamulizumab exhibited clinically meaningful antitumor activity in patients with relapsed PTCL and CTCL, with an acceptable toxicity profile. Further investigation of mogamulizumab for treatment of T-cell lymphoma is warranted. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.52.0924","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T04:24:17Z","timestamp":1394511857000},"page":"1157-1163","source":"Crossref","is-referenced-by-count":342,"title":["Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CC Chemokine Receptor 4 Antibody, in Patients With Relapsed Peripheral T-Cell Lymphoma and Cutaneous T-Cell Lymphoma"],"prefix":"10.1200","volume":"32","author":[{"given":"Michinori","family":"Ogura","sequence":"first","affiliation":[{"name":"Michinori Ogura, Nagoya Daini Red Cross Hospital; Takashi Ishida and Hiroshi Inagaki, Nagoya City University Graduate School of Medical Sciences; Kazuhito Yamamoto, Aichi Cancer Center; Ryuzo Ueda, Aichi Medical University School of Medicine, Nagoya; Kiyohiko Hatake, Japanese Foundation for Cancer Research; Kensei Tobinai, National Cancer Center Hospital; Shiro Akinaga, Kyowa Hakko Kirin, Tokyo; Masafumi Taniwaki, Kyoto Prefectural University of Medicine, Kyoto; Kiyoshi Ando, Tokai University School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ishida","sequence":"additional","affiliation":[{"name":"Michinori Ogura, Nagoya Daini Red Cross Hospital; Takashi Ishida and Hiroshi Inagaki, Nagoya City University Graduate School of Medical Sciences; Kazuhito Yamamoto, Aichi Cancer Center; Ryuzo Ueda, Aichi Medical University School of Medicine, Nagoya; Kiyohiko Hatake, Japanese Foundation for Cancer Research; Kensei Tobinai, National Cancer Center Hospital; Shiro Akinaga, Kyowa Hakko Kirin, Tokyo; Masafumi Taniwaki, Kyoto Prefectural University of Medicine, Kyoto; Kiyoshi Ando, Tokai University School of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Hatake","sequence":"additional","affiliation":[{"name":"Michinori Ogura, Nagoya Daini Red Cross Hospital; Takashi Ishida and Hiroshi Inagaki, Nagoya City University Graduate School of Medical Sciences; 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