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Although it may be appropriate to continue strong opioids in survivors with moderate to severe pain, most pain problems in cancer survivors will not require them. Moreover, because more than 40% of cancer survivors now live longer than 10 years, there is growing concern about the long-term adverse effects of opioids and the risks of misuse, abuse, and overdose in the nonpatient population. As with chronic nonmalignant pain, multimodal interventions that incorporate nonpharmacologic therapies should be part of the treatment strategy for pain in cancer survivors, prescribed with the aim of restoring functionality, not just providing comfort. For patients with complex pain issues, multidisciplinary programs should be used, if available. New or worsening pain in a cancer survivor must be evaluated to determine whether the cause is recurrent disease or a second malignancy. This article focuses on patients with a history of cancer who are beyond the acute diagnosis and treatment phase and on common treatment-related pain etiologies. The benefits and harms of the various pharmacologic and nonpharmacologic options for pain management in this setting are reviewed.<\/jats:p>","DOI":"10.1200\/jco.2013.52.4629","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T01:40:05Z","timestamp":1399340405000},"page":"1739-1747","source":"Crossref","is-referenced-by-count":295,"title":["Pain in Cancer Survivors"],"prefix":"10.1200","volume":"32","author":[{"given":"Paul A.","family":"Glare","sequence":"first","affiliation":[{"name":"Paul A. Glare, Amitabh Gulati, Dawn Lemanne, Natalie Moryl, Kevin C. Oeffinger, and Michael D. Stubblefield, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College; Pamela S. Davies, Esm\u00e9 Findlay, Judith A. Paice, and Karen L. 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