{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:20:45Z","timestamp":1790544045138,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,1,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To determine the influence of modifiable lifestyle factors on the risk of cardiovascular disease after hematopoietic cell transplantation (HCT). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> HCT survivors of \u2265 1 year treated from 1970 to 2010 (n = 3,833) were surveyed from 2010 to 2011 on current cardiovascular health and related lifestyle factors (smoking, diet, recreational physical activity). Responses (n = 2,362) were compared with those from a matched general population sample (National Health and Nutrition Examination Survey [NHANES]; n = 1,192). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Compared with NHANES participants, HCT survivors (median age, 55.9 years; median 10.8 years since HCT; 71.3% allogeneic) had higher rates of cardiomyopathy (4.0% v 2.6%), stroke (4.8% v 3.3%), dyslipidemia (33.9% v 22.3%), and diabetes (14.3% v 11.7%; P &lt; .05 for all comparisons). Prevalence of hypertension was similar (27.9% v 30.0%), and survivors were less likely to have ischemic heart disease (6.1% v 8.9%; P &lt; .01). Among HCT survivors, hypertension, dyslipidemia, and diabetes were independent risk factors for ischemic heart disease and cardiomyopathy, and smoking was associated with ischemic heart disease and diabetes (odds ratios [ORs], 1.8 to 2.1; P = .02). Obesity was a risk factor for post-transplantation hypertension, dyslipidemia, and diabetes (ORs \u2265 2.0; P &lt; .001). In contrast, lower fruit\/vegetable intake was associated with greater risk of dyslipidemia and diabetes (ORs, 1.4 to 1.8; P \u2264 .01), and lower physical activity level was associated with greater risk of hypertension and diabetes (ORs, 1.4 to 1.5; P &lt; .05). Healthier lifestyle characteristics among HCT survivors attenuated risk of all cardiovascular conditions assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Attention of clinicians to conventional cardiovascular risk factors and modifiable lifestyle characteristics offers hope of reducing serious cardiovascular morbidity after HCT. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2013.52.6582","type":"journal-article","created":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T05:09:54Z","timestamp":1386047394000},"page":"191-198","source":"Crossref","is-referenced-by-count":103,"title":["Influence of Conventional Cardiovascular Risk Factors and Lifestyle Characteristics on Cardiovascular Disease After Hematopoietic Cell Transplantation"],"prefix":"10.1200","volume":"32","author":[{"given":"Eric J.","family":"Chow","sequence":"first","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Scott","family":"Baker","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.D.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L.","family":"Cushing-Haugen","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Inamoto","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Khera","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. Martin, University of Washington, Seattle, WA; and Nandita Khera, Mayo Clinic, Phoenix, AZ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Leisenring","sequence":"additional","affiliation":[{"name":"Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, Kara L. Cushing-Haugen, Yoshihiro Inamoto, Wendy M. Leisenring, Karen L. Syrjala, and Paul J. Martin, Fred Hutchinson Cancer Research Center; Eric J. Chow, K. Scott Baker, Seattle Children's Hospital; Eric J. Chow, K. Scott Baker, Stephanie J. Lee, Mary E.D. Flowers, and Paul J. 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