{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:49:22Z","timestamp":1791190162332,"version":"4.1.0"},"reference-count":54,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precursors and whether their detection could be used as an early predictor for FL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants and Methods<\/jats:title>\n                    <jats:p>Among 520,000 healthy participants enrolled onto the EPIC (European Prospective Investigation Into Cancer and Nutrition) cohort, we identified 100 who developed FL 2 to 161 months after enrollment. Prediagnostic blood from these and 218 controls were screened for t(14;18) using sensitive polymerase chain reaction\u2013based assays. Results were subsequently validated in an independent cohort (65 case participants; 128 controls). Clonal relationships between t(14;18) cells and FL were also assessed by molecular backtracking of paired prediagnostic blood and tumor samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Clonal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated that progression to FL occurred from t(14;18)-positive committed precursors. Furthermore, healthy participants at enrollment who developed FL up to 15 years later showed a markedly higher t(14;18) prevalence and frequency than controls (P &lt; .001). Altogether, we estimated a 23-fold higher risk of subsequent FL in blood samples associated with a frequency &gt; 10\n                      <jats:sup>\u22124<\/jats:sup>\n                      (odds ratio, 23.17; 95% CI, 9.98 to 67.31; P &lt; .001). Remarkably, risk estimates remained high and significant up to 15 years before diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High t(14;18) frequency in blood from healthy individuals defines the first predictive biomarker for FL, effective years before diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2013.52.8190","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T02:15:08Z","timestamp":1396318508000},"page":"1347-1355","source":"Crossref","is-referenced-by-count":125,"title":["t(14;18) Translocation: A Predictive Blood Biomarker for Follicular Lymphoma"],"prefix":"10.1200","volume":"32","author":[{"given":"Sandrine","family":"Roulland","sequence":"first","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel S.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Morgado","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Sungalee","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Solal-Celigny","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Colombat","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jouve","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pala","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Tumino","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Panico","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Sacerdote","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R.","family":"Quir\u00f3s","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Gonz\u00e1les","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Jos\u00e9","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miren","family":"Dorronsoro","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Navarro","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Barricarte","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Olsen","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Overvad","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Canzian","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Drogan","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nieters","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; Philippe Solal-Celigny, Jean Bernard Center, Le Mans; Philippe Colombat, Bretonneau University Hospital, Tours; Fran\u00e7oise Clavel-Chapelon, INSERM U1018 Centre de Recherche en Epid\u00e9miologie et Sant\u00e9 des Populations..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Clavel-Chapelon","sequence":"additional","affiliation":[{"name":"Sandrine Roulland, Ester Morgado, St\u00e9phanie Sungalee, Nathalie Jouve, and Bertrand Nadel, Aix-Marseille Universit\u00e9, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1104, and Centre National de la Recherche Scientifique (CNRS) Unit\u00e9s Mixtes de Recherche (UMR) 7280, Marseille; 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