{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:33:56Z","timestamp":1791297236198,"version":"4.1.0"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Long-term central venous catheters (CVCs) are often used in patients with cancer to facilitate venous access to administer intravenous fluids and chemotherapy. CVCs can also be a source of bloodstream infections, although this risk is not well understood. We examined the impact of long-term CVC use on infection risk, independent of other risk factors such as chemotherapy, in a population-based cohort of patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis using SEER-Medicare data for patients age &gt; 65 years diagnosed from 2005 to 2007 with invasive colorectal, head and neck, lung, or pancreatic cancer, non-Hodgkin lymphoma, or invasive or noninvasive breast cancer. Cox proportional hazards regression was used to examine the relationship between CVC use and infections, with CVC exposure as a time-dependent predictor. We used multivariable analysis and propensity score methods to control for patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CVC exposure was associated with a significantly elevated infection risk, adjusting for demographic and disease characteristics. For patients with pancreatic cancer, risk of infections during the exposure period was three-fold greater (adjusted hazard ratio [AHR], 2.93; 95% CI, 2.58 to 3.33); for those with breast cancer, it was six-fold greater (AHR, 6.19; 95% CI, 5.42 to 7.07). Findings were similar when we accounted for propensity to receive a CVC and limited the cohort to individuals at high risk of infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long-term CVC use was associated with an increased risk of infections for older adults with cancer. Careful assessment of the need for long-term CVCs and targeted strategies for reducing infections are critical to improving cancer care quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2013.53.3018","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T09:47:41Z","timestamp":1404208061000},"page":"2351-2356","source":"Crossref","is-referenced-by-count":41,"title":["Long-Term Central Venous Catheter Use and Risk of Infection in Older Adults With Cancer"],"prefix":"10.1200","volume":"32","author":[{"given":"Allison","family":"Lipitz-Snyderman","sequence":"first","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent A.","family":"Sepkowitz","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena B.","family":"Elkin","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia S.","family":"Sima","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal H.","family":"Son","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral L.","family":"Atoria","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Bach","sequence":"additional","affiliation":[{"name":"All authors: Memorial Sloan Kettering Cancer Center, New York, 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