{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:01:15Z","timestamp":1792515675738,"version":"4.5.0"},"reference-count":70,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,10,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Risk-reducing salpingo-oophorectomy (RRSO) lowers mortality from ovarian\/tubal and breast cancers among BRCA1\/2 mutation carriers. Uncertainties persist regarding potential benefits of RRSO among high-risk noncarriers, optimal surgical age, and anatomic origin of clinically occult cancers detected at surgery. To address these topics, we analyzed surgical treatment arm results from Gynecologic Oncology Group Protocol-0199 (GOG-0199), the National Ovarian Cancer Prevention and Early Detection Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants and Methods<\/jats:title>\n                    <jats:p>This analysis included asymptomatic high-risk women age \u2265 30 years who elected RRSO at enrollment. Women provided risk factor data and underwent preoperative cancer antigen 125 (CA-125) serum testing and transvaginal ultrasound (TVU). RRSO specimens were processed according to a standardized tissue processing protocol and underwent central pathology panel review. Research-based BRCA1\/2 mutation testing was performed when a participant's mutation status was unknown at enrollment. Relationships between participant characteristics and diagnostic findings were assessed using univariable statistics and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Invasive or intraepithelial ovarian\/tubal\/peritoneal neoplasms were detected in 25 (2.6%) of 966 RRSOs (BRCA1 mutation carriers, 4.6%; BRCA2 carriers, 3.5%; and noncarriers, 0.5%; P &lt; .001). In multivariable models, positive BRCA1\/2 mutation status (P = .0056), postmenopausal status (P = .0023), and abnormal CA-125 levels and\/or TVU examinations (P &lt; .001) were associated with detection of clinically occult neoplasms at RRSO. For 387 women with negative BRCA1\/2 mutation testing and normal CA-125 levels, findings at RRSO were benign.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinically occult cancer was detected among 2.6% of high-risk women undergoing RRSO. BRCA1\/2 mutation, postmenopausal status, and abnormal preoperative CA-125 and\/or TVU were associated with cancer detection at RRSO. These data can inform management decisions among women at high risk of ovarian\/tubal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2013.54.1987","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:49:30Z","timestamp":1410223770000},"page":"3275-3283","source":"Crossref","is-referenced-by-count":121,"title":["Pathologic Findings at Risk-Reducing Salpingo-Oophorectomy: Primary Results From Gynecologic Oncology Group Trial GOG-0199"],"prefix":"10.1200","volume":"32","author":[{"given":"Mark E.","family":"Sherman","sequence":"first","affiliation":[{"name":"Mark E. Sherman, Phuong L. Mai, Lori Minasian, and Mark H. Greene, National Cancer Institute, Rockville; Olga B. Ioffe, University of Maryland Medical Center; Brigitte M. Ronnett, Johns Hopkins Medical Institutions, Baltimore; Chad A. Hamilton, Walter Reed National Military Medical Center, Bethesda, MD; Marion Piedmonte, Roswell Park Cancer Institute, Buffalo; Stephanie V. Blank, New York University School of Medicine; Noah D. Kauff, Memorial Sloan Kettering Cancer Center; New York, NY; Linda Van Le,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Piedmonte","sequence":"additional","affiliation":[{"name":"Mark E. Sherman, Phuong L. Mai, Lori Minasian, and Mark H. Greene, National Cancer Institute, Rockville; Olga B. Ioffe, University of Maryland Medical Center; Brigitte M. Ronnett, Johns Hopkins Medical Institutions, Baltimore; Chad A. Hamilton, Walter Reed National Military Medical Center, Bethesda, MD; Marion Piedmonte, Roswell Park Cancer Institute, Buffalo; Stephanie V. Blank, New York University School of Medicine; Noah D. Kauff, Memorial Sloan Kettering Cancer Center; New York, NY; Linda Van Le,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuong L.","family":"Mai","sequence":"additional","affiliation":[{"name":"Mark E. Sherman, Phuong L. Mai, Lori Minasian, and Mark H. 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