{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:23:46Z","timestamp":1791915826656,"version":"4.3.4"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,9,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To improve survival rates in children with acute myeloid leukemia (AML), we evaluated gemtuzumab-ozogamicin (GO), a humanized immunoconjugate targeted against CD33, as an alternative to further chemotherapy dose escalation. Our primary objective was to determine whether adding GO to standard chemotherapy improved event-free survival (EFS) and overall survival (OS) in children with newly diagnosed AML. Our secondary objectives examined outcomes by risk group and method of intensification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Children, adolescents, and young adults ages 0 to 29 years with newly diagnosed AML were enrolled onto Children's Oncology Group trial AAML0531 and then were randomly assigned to either standard five-course chemotherapy alone or to the same chemotherapy with two doses of GO (3 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/dose) administered once in induction course 1 and once in intensification course 2 (two of three).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There were 1,022 evaluable patients enrolled. GO significantly improved EFS (3 years: 53.1% v 46.9%; hazard ratio [HzR], 0.83; 95% CI, 0.70 to 0.99; P = .04) but not OS (3 years: 69.4% v 65.4%; HzR, 0.91; 95% CI, 0.74 to 1.13; P = .39). Although remission was not improved (88% v 85%; P = .15), posthoc analyses found relapse risk (RR) was significantly reduced among GO recipients overall (3 years: 32.8% v 41.3%; HzR, 0.73; 95% CI, 0.58 to 0.91; P = .006). Despite an increased postremission toxic mortality (3 years: 6.6% v 4.1%; HzR, 1.69; 95% CI, 0.93 to 3.08; P = .09), disease-free survival was better among GO recipients (3 years: 60.6% v 54.7%; HzR, 0.82; 95% CI, 0.67 to 1.02; P = .07).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GO added to chemotherapy improved EFS through a reduction in RR for children and adolescents with AML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2014.55.3628","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T02:25:29Z","timestamp":1407205529000},"page":"3021-3032","source":"Crossref","is-referenced-by-count":451,"title":["Gemtuzumab Ozogamicin in Children and Adolescents With De Novo Acute Myeloid Leukemia Improves Event-Free Survival by Reducing Relapse Risk: Results From the Randomized Phase III Children's Oncology Group Trial AAML0531"],"prefix":"10.1200","volume":"32","author":[{"given":"Alan S.","family":"Gamis","sequence":"first","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd A.","family":"Alonzo","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheil","family":"Meshinchi","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Gerbing","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana C.","family":"Raimondi","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betsy A.","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir B.","family":"Kahwash","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. Hirsch, University of Minnesota, Minneapolis, MN;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Heerema-McKenney","sequence":"additional","affiliation":[{"name":"Alan S. Gamis, Children's Mercy Hospitals and Clinics, Kansas City, MO; Todd A. Alonzo, University of Southern California, Los Angeles; Robert B. Gerbing, Children's Oncology Group, Monrovia; Amy Heerema-McKenney, Stanford University, Palo Alto, CA; Soheil Meshinchi, Fred Hutchinson Cancer Center; Laura Winter, Children's Hospital and Regional Medical Center, Seattle, WA; Susana C. Raimondi, St Jude Children's Research Hospital, Memphis, TN; Betsy A. 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