{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:10:53Z","timestamp":1793077853870,"version":"4.5.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We tested the efficacy and toxicity of cisplatin plus accelerated fractionation with a concomitant boost (AFX-C) versus standard fractionation (SFX) in locally advanced head and neck carcinoma (LA-HNC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Patients had stage III to IV carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. Radiation therapy schedules were 70 Gy in 35 fractions over 7 weeks (SFX) or 72 Gy in 42 fractions over 6 weeks (AFX-C). Cisplatin doses were 100 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      once every 3 weeks for two (AFX-C) or three (SFX) cycles. Toxicities were scored by using National Cancer Institute Common Toxicity Criteria 2.0 and the Radiation Therapy Oncology Group\/European Organisation for Research and Treatment of Cancer criteria. Overall survival (OS) and progression-free survival (PFS) rates were estimated by using the Kaplan-Meier method and were compared by using the one-sided log-rank test. Locoregional failure (LRF) and distant metastasis (DM) rates were estimated by using the cumulative incidence method and Gray's test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 721 of 743 patients were analyzable (361, SFX; 360, AFX-C). At a median follow-up of 7.9 years (range, 0.3 to 10.1 years) for 355 surviving patients, no differences were observed in OS (hazard ratio [HR], 0.96; 95% CI, 0.79 to 1.18; P = .37; 8-year survival, 48% v 48%), PFS (HR, 1.02; 95% CI, 0.84 to 1.24; P = .52; 8-year estimate, 42% v 41%), LRF (HR, 1.08; 95% CI, 0.84 to 1.38; P = .78; 8-year estimate, 37% v 39%), or DM (HR, 0.83; 95% CI, 0.56 to 1.24; P = .16; 8-year estimate, 15% v 13%). For oropharyngeal cancer, p16-positive patients had better OS than p16-negative patients (HR, 0.30; 95% CI, 0.21 to 0.42; P &lt; .001; 8-year survival, 70.9% v 30.2%). There were no statistically significant differences in the grade 3 to 5 acute or late toxicities between the two arms and p-16 status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When combined with cisplatin, AFX-C neither improved outcome nor increased late toxicity in patients with LA-HNC. Long-term high survival rates in p16-positive patients with oropharyngeal cancer support the ongoing efforts to explore deintensification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2014.55.3925","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:08:29Z","timestamp":1415059709000},"page":"3858-3867","source":"Crossref","is-referenced-by-count":422,"title":["Randomized Phase III Trial to Test Accelerated Versus Standard Fractionation in Combination With Concurrent Cisplatin for Head and Neck Carcinomas in the Radiation Therapy Oncology Group 0129 Trial: Long-Term Report of Efficacy and Toxicity"],"prefix":"10.1200","volume":"32","author":[{"given":"Phuc Felix","family":"Nguyen-Tan","sequence":"first","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Kian","family":"Ang","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal S.","family":"Weber","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. 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Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Kim","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. Rosenthal, University of Texas MD Anderson Cancer Center, Houston, TX; Harold Kim, Wayne State University, Detroit, MI;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Silverman","sequence":"additional","affiliation":[{"name":"Phuc Felix Nguyen-Tan and Denis Soulieres, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al H\u00f4pital Notre-Dame, Montreal; Andr\u00e9 Fortin, Centre Hospitalier Universitaire H\u00f4tel-Dieu de Qu\u00e9bec, Quebec City, Quebec, Canada; Qiang Zhang, NRG Oncology Statistics and Data Management Center; Thomas J. Galloway, Fox Chase Cancer Center, Philadelphia, PA; K. Kian Ang, Randal S. Weber, and David I. 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