{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:48:16Z","timestamp":1790635696168,"version":"4.1.0"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[2014,9,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>BCR-ABL1\u2013like acute lymphoblastic leukemia (ALL) is a recently identified B-cell ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to BCR-ABL1-positive ALL but lacks the BCR-ABL1 fusion protein. We examined the outcome of children with BCR-ABL1\u2013like ALL treated with risk-directed therapy based on minimal residual disease (MRD) levels during remission induction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Among 422 patients with B-ALL enrolled onto the Total Therapy XV study between 2000 and 2007, 344 had adequate samples for gene expression profiling. Next-generation sequencing and\/or analysis of genes known to be altered in B-ALL were performed in patients with BCR-ABL1\u2013like ALL who had available material. Outcome was compared between patients with and those without BCR-ABL1\u2013like ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty (11.6%) of the 344 patients had BCR-ABL1\u2013like ALL. They were significantly more likely to be male, have Down syndrome, and have higher MRD levels on day 19 and at the end of induction than did other patients with B-ALL. Among 25 patients comprehensively studied for genetic abnormalities, 11 harbored a genomic rearrangement of CRLF2, six had fusion transcripts responsive to ABL tyrosine kinase inhibitors or JAK inhibitors, and seven had mutations involving the Ras signaling pathway. There were no significant differences in event-free survival (90.0% \u00b1 4.7% [SE] v 88.4% \u00b1 1.9% at 5 years; P = .41) or in overall survival (92.5% \u00b1 4.2% v 95.1% \u00b1 1.3% at 5 years; P = .41) between patients with and without BCR-ABL1\u2013like ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients who have BCR-ABL1\u2013like ALL with poor initial treatment response can be salvaged with MRD-based risk-directed therapy and may benefit from identification of kinase-activating lesions for targeted therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2014.55.4105","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T21:39:40Z","timestamp":1405978780000},"page":"3012-3020","source":"Crossref","is-referenced-by-count":234,"title":["Outcomes of Children With\n                    <i>BCR-ABL1<\/i>\n                    \u2013Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease"],"prefix":"10.1200","volume":"32","author":[{"given":"Kathryn G.","family":"Roberts","sequence":"first","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. Sandlund, Sima Jeha, Wing H. Leung, Mary V. Relling, William E. Evans, and Ching-Hon Pui, University of Tennessee Health Science Center, Memphis, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqing","family":"Pei","sequence":"additional","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. Sandlund, Sima Jeha, Wing H. Leung, Mary V. Relling, William E. Evans, and Ching-Hon Pui, University of Tennessee Health Science Center, Memphis, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Campana","sequence":"additional","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. Sandlund, Sima Jeha, Wing H. Leung, Mary V. Relling, William E. Evans, and Ching-Hon Pui, University of Tennessee Health Science Center, Memphis, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Payne-Turner","sequence":"additional","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. Sandlund, Sima Jeha, Wing H. Leung, Mary V. Relling, William E. Evans, and Ching-Hon Pui, University of Tennessee Health Science Center, Memphis, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjin","family":"Li","sequence":"additional","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. Sandlund, Sima Jeha, Wing H. Leung, Mary V. Relling, William E. Evans, and Ching-Hon Pui, University of Tennessee Health Science Center, Memphis, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"All authors: St Jude Children's Research Hospital; and John T. 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