{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:05:40Z","timestamp":1792631140908,"version":"4.5.0"},"reference-count":101,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"27","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2015,9,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To review the impact of collaborative studies on advances in the biology and treatment of acute lymphoblastic leukemia (ALL) in children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A review of English literature on childhood ALL focusing on collaborative studies was performed. The resulting article was reviewed and revised by the committee chairs of the major ALL study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>With long-term survival rates for ALL approaching 90% and the advent of high-resolution genome-wide analyses, several international study groups or consortia were established to conduct collaborative research to further improve outcome. As a result, treatment strategies have been improved for several subtypes of ALL, such as infant, MLL-rearranged, Philadelphia chromosome\u2013positive, and Philadelphia chromosome\u2013like ALL. Many recurrent genetic abnormalities that respond to tyrosine kinase inhibitors and multiple genetic determinants of drug resistance and toxicities have been identified to help develop targeted therapy. Several genetic polymorphisms have been recognized that show susceptibility to developing ALL and that help explain the racial\/ethnic differences in the incidence of ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The information gained from collaborative studies has helped decipher the heterogeneity of ALL to help improve personalized treatment, which will further advance the current high cure rate and the quality of life for children and adolescents with ALL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2014.59.1636","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T22:03:48Z","timestamp":1440453828000},"page":"2938-2948","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":939,"title":["Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration"],"prefix":"10.1200","volume":"33","author":[{"given":"Ching-Hon","family":"Pui","sequence":"first","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schrappe","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Vora","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Baruchel","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis B.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Escherich","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Horibe","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves C.M.","family":"Benoit","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Izraeli","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen Eng Juh","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Der-Cherng","family":"Liang","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Downing","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Evans","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V.","family":"Relling","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles G.","family":"Mullighan","sequence":"additional","affiliation":[{"name":"Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.250"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.257"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.249"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70228-1"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.2070"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.103507"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.48.6522"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22620"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.5936"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70243-8"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.251"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.142"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.5020"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2287"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403365"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24354"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.276"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-248146"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-338707"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61126-X"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-273532"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07624.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08148.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.37"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24228"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25489"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534347"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08782-2"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402883"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-038299"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421402"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.1325"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70377-7"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808253"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70339-5"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1403088"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-509463"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110169"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2532"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.30"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.8280"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-462358"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4105"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12882"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.325"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.84"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/ng.469"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-08-235408"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.10.001"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208397"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811761106"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.06.005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.6770"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.095372"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.02.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122727"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2754"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/ng.432"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/ng.430"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ng.585"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt042"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-491316"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.302"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2803"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nature05690"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.205"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa033513"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.03.002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050083"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.7"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/ng1612"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.4156"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2430"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129668.111"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-256958"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22477"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.5.1643"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-563742"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-452839"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91745-V"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.12.1485"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.316"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.23.2001"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.8.2293"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4671"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.0894"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.6399"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.020"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-123885"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2011.00664.x"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-381731"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.3557"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70452-2"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-130237"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.053"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.0325"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12097"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2014.59.1636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:03:10Z","timestamp":1653508990000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2014.59.1636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,20]]},"references-count":101,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2015,9,20]]}},"alternative-id":["10.1200\/JCO.2014.59.1636"],"URL":"https:\/\/doi.org\/10.1200\/jco.2014.59.1636","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,20]]},"assertion":[{"value":"2015-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}