{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:55:47Z","timestamp":1792108547954,"version":"4.4.0"},"reference-count":43,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"17","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2015,6,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Musculoskeletal symptoms are the most common adverse effects of aromatase inhibitors (AIs) and can result in decreased quality of life and discontinuation of therapy. Omega-3 fatty acids (O3-FAs) can be effective in decreasing arthralgia resulting from rheumatologic conditions and reducing serum triglycerides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>Women with early-stage breast cancer receiving an AI who had a worst joint pain\/stiffness score \u2265 5 of 10 using the Brief Pain Inventory\u2013Short Form (BPI-SF) were randomly assigned to receive either O3-FAs 3.3 g or placebo (soybean\/corn oil) daily for 24 weeks. Clinically significant change was defined as \u2265 2-point drop from baseline. Patients also completed quality-of-life (Functional Assessment of Cancer Therapy\u2013Endocrine Symptoms) and additional pain\/stiffness assessments at baseline and weeks 6, 12, and 24. Serial fasting blood was collected for lipid analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 262 patients registered, 249 were evaluable, with 122 women in the O3-FA arm and 127 in the placebo arm. Compared with baseline, the mean observed BPI-SF score decreased by 1.74 points at 12 weeks and 2.22 points at 24 weeks with O3-FAs and by 1.49 and 1.81 points, respectively, with placebo. In a linear regression adjusting for the baseline score, osteoarthritis, and taxane use, adjusted 12-week BPI-SF scores did not differ by arm (P = .58). Triglyceride levels decreased in patients receiving O3-FA treatment and remained the same for those receiving placebo (P = .01). No between-group differences were seen for HDL, LDL, or C-reactive protein.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a substantial (&gt; 50%) and sustained improvement in AI arthralgia for both O3-FAs and placebo but found no meaningful difference between the groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2014.59.5595","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T22:04:00Z","timestamp":1430777040000},"page":"1910-1917","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":92,"title":["Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor\u2013Induced Musculoskeletal Pain: SWOG S0927"],"prefix":"10.1200","volume":"33","author":[{"given":"Dawn L.","family":"Hershman","sequence":"first","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Unger","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Crew","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Awad","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker R.","family":"Dakhil","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gralow","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Greenlee","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danika L.","family":"Lew","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori M.","family":"Minasian","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathee","family":"Till","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"James L.","family":"Wade","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Meyskens","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol M.","family":"Moinpour","sequence":"additional","affiliation":[{"name":"Dawn L. Hershman, Katherine D. Crew, Danielle Awad, and Heather Greenlee, Columbia University Medical Center, New York, NY; Joseph M. Unger, Danika L. Lew, and Cathee Till, Southwest Oncology Group Statistical Center; Joseph M. Unger, Julie Gralow, Danika L. Lew, Cathee Till, and Carol M. Moinpour, Fred Hutchinson Cancer Research Center, Seattle, WA; Shaker R. Dakhil, Cancer Center of Kansas, Wichita, KS; Lori M. Minasian, National Cancer Institute, Bethesda, MD; James L. Wade III, Central Illinois..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3756"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70257-6"},{"key":"B3","volume-title":"Presented at the 32nd San Antonio Breast Cancer Symposium","author":"Crew KD"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25385"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24419"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70182-7"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9655"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.4.1336"},{"key":"B9","first-page":"1471","volume":"15","author":"Cleland LG","year":"1988","journal-title":"J Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/147323000403200501"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92024-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330607"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01431.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3109\/03009749209099218"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262088"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.01.020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2005.10.023"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2013.10.003"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504133321501"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.598"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2294-z"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00101-3"},{"key":"B23","first-page":"1833","volume":"15","author":"Bellamy N","year":"1988","journal-title":"J Rheumatol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh360"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.3.974"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1179\/jmt.2009.17.3.163"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4708"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/BF00713400"},{"key":"B29","first-page":"584","volume":"87","author":"Friedrichs K","year":"1998","journal-title":"Praxis (Bern 1994)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00155-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/jclp.20129"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105243442106"},{"key":"B33","first-page":"CD001395","volume":"12","author":"Lethaby A","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09088-8"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26230"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200629090-00003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.10.034"},{"key":"B38","first-page":"2331","volume":"32","author":"Kubo M","year":"2012","journal-title":"Anticancer Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.11.1653"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.5435"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020571617274"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.0236"},{"key":"B43","first-page":"2259","volume":"34","author":"Laroche M","year":"2007","journal-title":"J Rheumatol"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2014.59.5595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T19:53:28Z","timestamp":1653508408000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2014.59.5595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":43,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2015,6,10]]}},"alternative-id":["10.1200\/JCO.2014.59.5595"],"URL":"https:\/\/doi.org\/10.1200\/jco.2014.59.5595","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]},"assertion":[{"value":"2015-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}