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Hence, investigators must rely on retrospective analyses to understand the disease and its appropriate treatment. The current understanding of SCCUP differs substantially from when it was initially described decades ago. The most common site of a small primary tumor initially thought to represent SCCUP is the tonsil or base of the tongue, and an increasing percentage are associated with human papilloma virus. Modern treatment of SCCUP by neck dissection alone, neck dissection followed by radiation with or without concurrent chemotherapy, or primary chemoradiation according to initial nodal disease burden produces extraordinarily low recurrence rates. Whether the potential mucosal primary site and\/or the contralateral neck should be electively treated is controversial. Efficacy data seem to be similar; therefore, an evaluation of the toxicity of both treatment paradigms is warranted.<\/jats:p>","DOI":"10.1200\/jco.2015.61.0063","type":"journal-article","created":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T02:29:51Z","timestamp":1441765791000},"page":"3328-3337","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":103,"title":["Management of Squamous Cancer Metastatic to Cervical Nodes With an Unknown Primary Site"],"prefix":"10.1200","volume":"33","author":[{"given":"Thomas J.","family":"Galloway","sequence":"first","affiliation":[{"name":"All authors: Fox Chase Cancer Center, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"All authors: Fox Chase Cancer Center, Philadelphia, 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