{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:52:00Z","timestamp":1791229920867,"version":"4.1.0"},"reference-count":22,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"7","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Obesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss is in-person counseling, but telephone counseling may be more feasible. We examined the effect of in-person versus telephone weight loss counseling versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred breast cancer survivors with a body mass index \u2265 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were randomly assigned to in-person counseling (n = 33), telephone counseling (n = 34), or usual care (UC) (n = 33). In-person and telephone counseling included 11 30-minute counseling sessions over 6 months. These focused on reducing caloric intake, increasing physical activity, and behavioral therapy. Body composition, physical activity, diet, and serum biomarkers were measured at baseline and 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants was 59 \u00b1 7.5 years old, with a mean BMI of 33.1 \u00b1 6.6 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , and the mean time from diagnosis was 2.9 \u00b1 2.1 years. Fifty-one percent of the participants had stage I breast cancer. Average 6-month weight loss was 6.4%, 5.4%, and 2.0% for in-person, telephone, and UC groups, respectively (P = .004, P = .009, and P = .46 comparing in-person with UC, telephone with UC, and in-person with telephone, respectively). A significant 30% decrease in C-reactive protein levels was observed among women randomly assigned to the combined weight loss intervention groups compared with a 1% decrease among women randomly assigned to UC (P = .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both in-person and telephone counseling were effective weight loss strategies, with favorable effects on C-reactive protein levels. Our findings may help guide the incorporation of weight loss counseling into breast cancer treatment and care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2015.61.6375","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T22:19:21Z","timestamp":1448317161000},"page":"669-676","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":173,"title":["Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study"],"prefix":"10.1200","volume":"34","author":[{"given":"Maura","family":"Harrigan","sequence":"first","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Cartmel","sequence":"additional","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erikka","family":"Loftfield","sequence":"additional","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Sanft","sequence":"additional","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anees B.","family":"Chagpar","sequence":"additional","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. 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