{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:48:45Z","timestamp":1792802925871,"version":"4.5.0"},"reference-count":34,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"34","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Routine imaging for diffuse large B-cell lymphoma (DLBCL) in first complete remission (CR) is controversial and plays a limited role in detecting relapse. This population-based study compared the survival of Danish and Swedish patients with DLBCL for whom traditions for routine imaging have been different. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Patients from the Danish and Swedish lymphoma registries were included according to the following criteria: newly diagnosed DLBCL from 2007 to 2012, age 18 to 65 years, and CR after R-CHOP\/CHOEP. Follow-up for Swedish patients included symptom assessment, clinical examinations, and blood tests at 3- to 4-month intervals for 2 years, with longer intervals later in follow-up. Imaging was only recommended when relapse was clinically suspected. Follow-up for Danish patients was similar but included routine imaging (usually computed tomography every 6 months for 2 years). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Danish (n = 525) and Swedish (n = 696) patients with DLBCL had comparable baseline characteristics. Cumulative 2-year progression rate after CR was 6% (95% CI, 4 to 9) for International Prognostic Index (IPI) \u2264 2 versus 21% (95% CI, 13 to 28) for IPI &gt; 2. Age &gt; 60 years (hazard ratio [HR], 2.3; 95% CI, 1.6 to 3.4), elevated lactate dehydrogenase (HR, 2.3; 95% CI, 1.4 to 3.8), B symptoms (HR, 1.7; 95% CI, 1.1 to 2.5), and Eastern Cooperative Oncology Group performance status \u2265 2 (HR, 1.8; 95% CI, 1.0 to 3.0) were associated with worse post-CR survival. Imaging-based follow-up strategy had no impact on survival, neither for all patients nor for IPI-specific subgroups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> DLBCL relapse after first CR is infrequent, and the widespread use of routine imaging in Denmark did not translate into better survival. This favors follow-up without routine imaging and, more generally, a shift of focus from relapse detection to improved survivorship. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2015.62.0229","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T02:58:53Z","timestamp":1444100333000},"page":"3993-3998","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":82,"title":["Routine Imaging for Diffuse Large B-Cell Lymphoma in First Complete Remission Does Not Improve Post-Treatment Survival: A Danish\u2013Swedish Population-Based Study"],"prefix":"10.1200","volume":"33","author":[{"given":"Tarec Christoffer","family":"El-Galaly","sequence":"first","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse Hjort","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"de Nully Brown","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Nilsson-Ehle","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Juul","family":"Mylam","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Hjalmar","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; Elisabeth Sz\u00e9kely and Mats Jerkeman, Lund University Hospital..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Erik","family":"Johnsen","sequence":"additional","affiliation":[{"name":"Tarec Christoffer El-Galaly, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University Hospital; Tarec Christoffer El-Galaly, Lasse Hjort Jakobsen, Hans Erik Johnsen, and Martin B\u00f8gsted, Aalborg University, Aalborg; Martin Hutchings and Peter de Nully Brown, Rigshospitalet, Copenhagen University Hospital, Copenhagen; Karen Juul Mylam, Odense University Hospital, Odense, Denmark; Herman Nilsson-Ehle, Sahlgrenska University Hospital, Gothenburg; 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