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Although all TKIs are associated with nonhematologic adverse events (AEs), experience with imatinib suggested that toxicities are typically manageable and apparent early during drug development. Recent reports of cardiovascular AEs with nilotinib and particularly ponatinib and of pulmonary arterial hypertension with dasatinib have raised concerns about long-term sequelae of drugs that may be administered for decades. Here, we review what is currently known about the cardiovascular toxicities of BCR-ABL1 TKIs, discuss potential mechanisms underlying cardiovascular AEs, and elucidate discrepancies between the reporting of such AEs between oncology and cardiovascular trials. Whenever possible, we provide practical recommendations, but we concede that cause-directed interventions will require better mechanistic understanding. We suggest that chronic myeloid leukemia heralds a fundamental shift in oncology toward effective but mostly noncurative long-term therapies. Realizing the full potential of these treatments will require a proactive rational approach to minimize long-term cardiovascular and cardiometabolic toxicities.<\/jats:p>","DOI":"10.1200\/jco.2015.62.4718","type":"journal-article","created":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T20:30:38Z","timestamp":1442262638000},"page":"4210-4218","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":398,"title":["Tyrosine Kinase Inhibitor\u2013Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia"],"prefix":"10.1200","volume":"33","author":[{"given":"Javid J.","family":"Moslehi","sequence":"first","affiliation":[{"name":"Javid J. 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