{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:24:47Z","timestamp":1791869087003,"version":"4.3.4"},"reference-count":11,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"6","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2016,2,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> To compare short-course radiotherapy (RT) (4 Gy \u00d7 5) to longer-course RT (3 Gy \u00d7 10) for metastatic epidural spinal cord compression (MESCC). <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> Two-hundred three patients with MESCC and poor to intermediate expected survival were randomly assigned to 4 Gy \u00d7 5 in 1 week (n = 101) or 3 Gy \u00d7 10 in 2 weeks (n = 102). Patients were stratified according to ambulatory status, time developing motor deficits, and primary tumor type. Seventy-eight and 77 patients, respectively, were evaluable for the primary end point, 1-month overall response regarding motor function defined as improvement or no further progression of motor deficits. Other study end points included ambulatory status, local progression-free survival, and overall survival. End points were evaluated immediately after RT and at 1, 3, and 6 months thereafter. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> At 1 month, overall response rates regarding motor function were 87.2% after 4 Gy \u00d7 5 and 89.6% after 3 Gy \u00d7 10 (P = .73). Improvement rates were 38.5% and 44.2%, respectively, no further progression rates 48.7% and 45.5%, respectively, and deterioration rates 12.8% and 10.4%, respectively (P = .44). Ambulatory rates at 1 month were 71.8% and 74.0%, respectively (P = .86). At other times after RT, the results were also not significantly different. Six-month local progression-free survival was 75.2% after 4 Gy \u00d7 5 and 81.8% after 3 Gy \u00d7 10 (P = .51); 6-month overall survival was 42.3% and 37.8% (P = .68). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Short-course RT with 4 Gy \u00d7 5 was not significantly inferior to 3 Gy \u00d7 10 in patients with MESCC and poor to intermediate expected survival. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2015.64.0862","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T02:30:08Z","timestamp":1451961008000},"page":"597-602","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":109,"title":["Radiotherapy With 4 Gy \u00d7 5 Versus 3 Gy \u00d7 10 for Metastatic Epidural Spinal Cord Compression: Final Results of the SCORE-2 Trial (ARO 2009\/01)"],"prefix":"10.1200","volume":"34","author":[{"given":"Dirk","family":"Rades","sequence":"first","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"\u0160egedin","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Conde-Moreno","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Garcia","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Perpar","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Metz","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harun","family":"Badakhshi","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. 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Adamietz, Ruhr University Bochum, Bochum, Germany; Barbara \u0160egedin and Ana Perpar, Institute of Oncology..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Schulze","sequence":"additional","affiliation":[{"name":"Dirk Rades, University of L\u00fcbeck, L\u00fcbeck; Michaela Metz, University of W\u00fcrzburg, W\u00fcrzburg; Harun Badakhshi, Charite Berlin, Berlin; Andreas Schreiber, Radiotherapy Practice Dresden-Friedrichstadt, Dresden; Mirko Nitsche, Center of Radiotherapy, Bremen; Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg; Wolfgang Schulze, Klinikum Bayreuth, Bayreuth; Irenaeus A. 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