{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:33:49Z","timestamp":1791221629246,"version":"4.1.0"},"reference-count":51,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"9","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2016,3,20]]},"DOI":"10.1200\/jco.2015.65.8427","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T02:44:15Z","timestamp":1454640255000},"page":"987-1011","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":153,"title":["Clinical Cancer Advances 2016: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology"],"prefix":"10.1200","volume":"34","author":[{"given":"Don S.","family":"Dizon","sequence":"first","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lada","family":"Krilov","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Cohen","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Gangadhar","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Ganz","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Hensing","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hunger","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smitha S.","family":"Krishnamurthi","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Lassman","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merry Jennifer","family":"Markham","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Mayer","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Neuss","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanta Kumar","family":"Pal","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa C.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Schilsky","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Spriggs","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Villalona-Calero","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Villani","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Masters","sequence":"additional","affiliation":[{"name":"Don S. Dizon, Massachusetts General Hospital, Boston; Erica Mayer, Dana-Farber Cancer Institute, Boston, MA; Lada Krilov and Richard Schilsky, American Society of Clinical Oncology, Alexandria, VA; Ezra Cohen, University of California San Diego, San Diego; Patricia A. Ganz, University of California Los Angeles, Los Angeles; Sumanta Kumar Pal, City of Hope Comprehensive Cancer Center, Duarte, CA; Tara Gangadhar, University of Pennsylvania; Stephen Hunger, Children's Hospital Center of Philadelphia,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6449a1"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503093"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70076-8"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414428"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3708"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501824"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.8007"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.32.15_suppl.8024"},{"key":"b20","doi-asserted-by":"crossref","unstructured":"J Vansteenkiste, L Fehrenbacher, AI Spira, etal: Atezolizumab monotherapy vs docetaxel in 2L\/3L non-small cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR). Presented at the European Cancer Congress, Vienna, Austria, September 25-29, 2015 (abstr 14LBA)","DOI":"10.1016\/S0959-8049(15)30072-1"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1038\/nature13904"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.0703"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510665"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411087"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500596"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71170-2"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1407222"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2025"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70137-7"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405044"},{"key":"b38","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv086"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6429a3"},{"key":"b43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412379"},{"key":"b45","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3741"},{"key":"b48","first-page":"429","volume":"12","author":"Awad MM","year":"2014","journal-title":"Clin Adv Hematol Oncol"},{"key":"b49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406766"},{"key":"b53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501548"},{"key":"b57","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70228-1"},{"key":"b58","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71135-0"},{"key":"b59","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70391-2"},{"key":"b60","unstructured":"JA Ledermann, TJ Perren, FA Raja, etal: Randomized double-blind phase III trial of cediranib (AZD 2171) in relapsed platinum-sensitive ovarian cancer: Results of the ICON6 trial. Presented at the European Cancer Congress, Amsterdam, Netherlands, September 30, 2013 (abstr 10)"},{"key":"b62","doi-asserted-by":"publisher","DOI":"10.1038\/nature14410"},{"key":"b63","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71159-3"},{"key":"b65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505270"},{"key":"b66","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510016"},{"key":"b67","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70473-5"},{"key":"b71","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506007"},{"key":"b73","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414882"},{"key":"b74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504473"},{"key":"b75","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415340"},{"key":"b76","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1415369"},{"key":"b78","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.9747"},{"key":"b81","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.1145"},{"key":"b82","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.5161"},{"key":"b83","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.6362"},{"key":"b84","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.7824"},{"key":"b85","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.2014.1055"},{"key":"b87","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp263"},{"key":"b88","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.8983"}],"updated-by":[{"DOI":"10.1200\/jco.2016.70.4304","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000}}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2015.65.8427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:48:25Z","timestamp":1653511705000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2015.65.8427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,20]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,3,20]]}},"alternative-id":["10.1200\/JCO.2015.65.8427"],"URL":"https:\/\/doi.org\/10.1200\/jco.2015.65.8427","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,20]]},"assertion":[{"value":"2016-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}