{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:20Z","timestamp":1791475520838,"version":"4.3.4"},"reference-count":26,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2016,12,20]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived \u2265 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency (9.2%), and thyroidal hypothyroidism (5.8%). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95% CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95% CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95% CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95% CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95% CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95% CI, 1.48 to 4.74) tumor site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2016.67.5025","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T13:24:06Z","timestamp":1476192246000},"page":"4362-4370","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":97,"title":["Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study"],"prefix":"10.1200","volume":"34","author":[{"given":"Sarah C.","family":"Clement","sequence":"first","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette Y.N.","family":"Schouten-van Meeteren","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke M.","family":"Boot","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy L.","family":"Claahsen-van der Grinten","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Granzen","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Sen Han","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert O.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna M.","family":"Michiels","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S. Paul","family":"van Trotsenburg","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Peter","family":"Vandertop","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dannis G.","family":"van Vuurden","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C.M.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert N.","family":"Caron","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke M.","family":"van Santen","sequence":"additional","affiliation":[{"name":"Sarah C. Clement, K. Sen Han, and Hanneke M. van Santen, University Medical Center Utrecht, Utrecht; Sarah C. Clement, Antoinette Y.N. Schouten-van Meeteren, A.S. Paul van Trotsenburg, W. Peter Vandertop, Leontien C.M. Kremer, and Hubert N. Caron, Academic Medical Center, University of Amsterdam; W. Peter Vandertop and Dannis G. van Vuurden, Vrije Universiteit University Medical Center, Amsterdam; Annemieke M. Boot, University Medical Center Groningen, University of Groningen, Groningen; Hedy L. Claahsen..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0988"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809341709"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1385-6"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.12.006"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1037\/a0016674"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.7933"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-1043"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25176"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.13.5293"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00779"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-2028"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.1931004.x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/adc.74.6.490"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/adc.77.1.32"},{"key":"B20","first-page":"175","volume":"7","author":"Hopwood NJ","year":"1985","journal-title":"Spec Top Endocrinol Metab"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198906000-00001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1976.tb01955.x"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031224"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1500329"},{"key":"B25","first-page":"4472","volume":"84","author":"Rose SR","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.1.55"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1667\/RR2240.1"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0576"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1839"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26403"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24445"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2016.67.5025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T05:53:29Z","timestamp":1653803609000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2016.67.5025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":26,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2016,12,20]]}},"alternative-id":["10.1200\/JCO.2016.67.5025"],"URL":"https:\/\/doi.org\/10.1200\/jco.2016.67.5025","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]},"assertion":[{"value":"2016-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}