{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:45:53Z","timestamp":1792118753103,"version":"4.4.0"},"reference-count":35,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"33","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2016,11,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity in one of the pathways influenced by nitrogen-containing bisphosphonates, which are associated with improved survival in multiple myeloma (MM). To understand the benefit of statins in MM, we evaluated the association between statin use and mortality in a large cohort of patients with MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>From the Veterans Administration Central Cancer Registry, we identified patients diagnosed with MM between 1999 and 2013. We defined statin use as the presence of any prescription for a statin within 3 months before or any time after MM diagnosis. Cox proportional hazards regression assessed the association of statin use with mortality, while controlling for known MM prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified a cohort of 4,957 patients, of whom 2,294 received statin therapy. Statin use was associated with a 21% decrease in all-cause mortality (adjusted hazard ratio, 0.79; 95% CI, 0.73 to 0.86; P &lt; .001) as well as a 24% decrease in MM-specific mortality (adjusted hazard ratio, 0.76; 95% CI, 0.67 to 0.86; P &lt; .001). This association remained significant across all sensitivity analyses. In addition to reductions in mortality, statin use was associated with a 31% decreased risk of developing a skeletal-related event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this cohort study of US veterans with MM, statin therapy was associated with a reduced risk of both all-cause and MM-specific mortality. Our findings suggest a potential role for statin therapy in patients with MM. The putative benefit of statin therapy in MM should be corroborated in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2016.68.3482","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T02:40:03Z","timestamp":1474339203000},"page":"4008-4014","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":87,"title":["Statins Are Associated With Reduced Mortality in Multiple Myeloma"],"prefix":"10.1200","volume":"34","author":[{"given":"Kristen Marie","family":"Sanfilippo","sequence":"first","affiliation":[{"name":"Kristen Marie Sanfilippo, Suhong Luo, Jason Gumbel, and Kenneth R. Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. Carson, Washington University School of Medicine; Brandon Blue, St Louis University, St Louis, MO; and Tzu-Fei Wang, The Ohio State University Comprehensive Cancer Center, Columbus, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Keller","sequence":"additional","affiliation":[{"name":"Kristen Marie Sanfilippo, Suhong Luo, Jason Gumbel, and Kenneth R. Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. Carson, Washington University School of Medicine; Brandon Blue, St Louis University, St Louis, MO; and Tzu-Fei Wang, The Ohio State University Comprehensive Cancer Center, Columbus, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian F.","family":"Gage","sequence":"additional","affiliation":[{"name":"Kristen Marie Sanfilippo, Suhong Luo, Jason Gumbel, and Kenneth R. Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. Carson, Washington University School of Medicine; Brandon Blue, St Louis University, St Louis, MO; and Tzu-Fei Wang, The Ohio State University Comprehensive Cancer Center, Columbus, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Kristen Marie Sanfilippo, Suhong Luo, Jason Gumbel, and Kenneth R. Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. 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Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. Carson, Washington University School of Medicine; Brandon Blue, St Louis University, St Louis, MO; and Tzu-Fei Wang, The Ohio State University Comprehensive Cancer Center, Columbus, OH."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gumbel","sequence":"additional","affiliation":[{"name":"Kristen Marie Sanfilippo, Suhong Luo, Jason Gumbel, and Kenneth R. Carson, St Louis Veterans Health Administration Medical Center; Kristen Marie Sanfilippo, Jesse Keller, Brian F. Gage, Gerald Moskowitz, Katiuscia O\u2019Brian, and Kenneth R. 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