{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:32:25Z","timestamp":1791311545395,"version":"4.3.1"},"reference-count":38,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2017,2,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Follicular lymphoma (FL) is an indolent cancer, with effective but rarely curative treatment options. As a standard study end point for first-line FL therapy, progression-free survival (PFS) requires extended follow-up (median PFS, &gt; 7 years). To provide patients with earlier access to newer therapies, an earlier end point to expedite clinical trials is needed. Our objective was to formally assess the complete response rate at 30 months (CR30) after initiation of induction therapy as a potential surrogate end point for PFS in first-line FL therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p> We analyzed individual patient data from 13 randomized multicenter trials of induction and maintenance regimens in first-line FL therapy published after 1990 and with sufficient data to evaluate whether CR30 could predict treatment effects on PFS. Correlation of the CR30 odds ratio with the PFS hazard ratio was evaluated by both linear regression (R<jats:sup>2<\/jats:sup><jats:sub>WLS<\/jats:sub>) and bivariate copula (R<jats:sup>2<\/jats:sup><jats:sub>Copula<\/jats:sub>) models. Prespecified criteria for surrogacy required either R<jats:sup>2<\/jats:sup><jats:sub>WLS<\/jats:sub> or R<jats:sup>2<\/jats:sup><jats:sub>Copula<\/jats:sub> \u2265 0.80, with a lower-bound 95% CI &gt; 0.60. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Data from eight induction and five maintenance randomized trials in 3,837 evaluable patients were analyzed. The prespecified surrogacy threshold was met, with an R<jats:sup>2<\/jats:sup><jats:sub>WLS<\/jats:sub> of 0.88 (95% CI, 0.77 to 0.96) and an R<jats:sup>2<\/jats:sup><jats:sub>Copula<\/jats:sub> of 0.86 (95% CI, 0.72 to 1.00). Multiple sensitivity and supplemental analyses supported the robustness of the findings. A minimum 11% absolute improvement in CR30 from a 50% control rate predicted a significant treatment effect on PFS (hazard ratio, 0.69). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> This large, prospective, pooled analysis of randomized chemotherapy, immunotherapy, and chemoimmunotherapy trials demonstrates that CR30 is a surrogate end point for PFS in first-line FL treatment trials. Use of this end point may expedite therapeutic development with the intent of bringing novel therapies to this patient population years before PFS results are mature. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2016.70.8651","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T11:56:50Z","timestamp":1487937410000},"page":"552-560","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":106,"title":["Thirty-Month Complete Response as a Surrogate End Point in First-Line Follicular Lymphoma Therapy: An Individual Patient-Level Analysis of Multiple Randomized Trials"],"prefix":"10.1200","volume":"35","author":[{"given":"Qian","family":"Shi","sequence":"first","affiliation":[{"name":"Qian Shi and Daniel J. Sargent, Mayo Clinic, Rochester; Bruce A. Peterson, University of Minnesota, Minneapolis, MN; Christopher R. Flowers, Winship Cancer Institute of Emory University, Atlanta, GA; Wolfgang Hiddemann and Eva Hoster, Ludwig-Maximilians University Hospital, Munich; Michael Herold, HELIOS Kliniken, Erfurt, Germany; Robert Marcus, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom; Anton Hagenbeek, Academic Medical Center, Amsterdam, the Netherlands; Eva Kimby, Karolinska Institutet,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Flowers","sequence":"additional","affiliation":[{"name":"Qian Shi and Daniel J. Sargent, Mayo Clinic, Rochester; Bruce A. Peterson, University of Minnesota, Minneapolis, MN; Christopher R. 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