{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:31:44Z","timestamp":1785900704461,"version":"3.56.0"},"reference-count":25,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"36","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2017,12,20]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p> Treatment of oropharyngeal squamous cell carcinoma (OPSCC) is evolving toward risk-based modification of therapeutic intensity, which requires patient-specific estimates of overall survival (OS) and progression-free survival (PFS). <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> To develop and validate nomograms for OS and PFS, we used a derivation cohort of 493 patients with OPSCC with known p16 tumor status (surrogate of human papillomavirus) and cigarette smoking history (pack-years) randomly assigned to clinical trials using platinum-based chemoradiotherapy (NRG Oncology Radiation Therapy Oncology Group [RTOG] 0129 and 0522). Nomograms were created from Cox models and internally validated by use of bootstrap and cross-validation. Model discrimination was measured by calibration plots and the concordance index. Nomograms were externally validated in a cohort of 153 patients with OPSCC randomly assigned to a third trial, NRG Oncology RTOG 9003. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Both models included age, Zubrod performance status, pack-years, education, p16 status, and T and N stage; the OS model also included anemia and age \u00d7 pack-years interaction; and the PFS model also included marital status, weight loss, and p16 \u00d7 Zubrod interaction. Predictions correlated well with observed 2-year and 5-year outcomes. The uncorrected concordance index was 0.76 (95% CI, 0.72 to 0.80) for OS and 0.70 (95% CI, 0.66 to 0.74) for PFS, and bias-corrected indices were similar. In the validation set, OS and PFS models were well calibrated, and OS and PFS were significantly different across tertiles of nomogram scores (log-rank P = .003;&lt; .001). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> The validated nomograms provided useful prediction of OS and PFS for patients with OPSCC treated with primary radiation-based therapy. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2016.72.0748","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T19:55:17Z","timestamp":1501876517000},"page":"4057-4065","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":126,"title":["Development and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer"],"prefix":"10.1200","volume":"35","author":[{"given":"Carole","family":"Fakhry","sequence":"first","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phuc Felix","family":"Nguyen-T\u00e2n","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal S.","family":"Weber","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Lambert","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Andy M.","family":"Trotti","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade L.","family":"Thorstad","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher U.","family":"Jones","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue S.","family":"Yom","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Ridge","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam S.D.","family":"Rao","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Bonner","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vigneault","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Raben","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh R.","family":"Kudrimoti","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Harris","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quynh-Thu","family":"Le","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura L.","family":"Gillison","sequence":"additional","affiliation":[{"name":"Carole Fakhry, Johns Hopkins University, Baltimore, MD; Qiang Zhang and Jonathan Harris, NRG Oncology Statistics and Data Management Center, American College of Radiology; John A. Ridge, Fox Chase Cancer Center, Philadelphia, PA; Phuc Felix Nguyen-T\u00e2n and Louise Lambert, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal; Eric Vigneault, L'Hotel-Dieu de Quebec, Ville de Qu\u00e9bec, Quebec, Canada; David I. Rosenthal, Randal S. Weber, and Maura L. Gillison, MD Anderson Cancer Center, Houston, TX; Andy M..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0912217"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.0164"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"B5","doi-asserted-by":"crossref","unstructured":"Ang KK, Zhang QE, Rosenthal DI, et al: A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC). J Clin Oncol 29:5500, 2011 (suppl)","DOI":"10.1200\/jco.2011.29.15_suppl.5500"},{"key":"B6","first-page":"79","volume":"5","author":"RTOG 0522:","year":"2007","journal-title":"Clin Adv Hematol Oncol"},{"key":"B7","unstructured":"Flaming I, Cooper J, Henson D, et al: AJCC Cancer Staging Manual (ed 5). Philadelphia, PA, Lippincott-Raven, 1997"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00663-5"},{"key":"B9","first-page":"6469","volume":"9","author":"Begum S","year":"2003","journal-title":"Clin Cancer Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318253a2d1"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.42"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"B13","first-page":"163","volume":"50","author":"Mantel N","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.12.018"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"B17","unstructured":"Westfall PH, Hochberg Y, Rom D, et al: Multiple Comparisons and Multiple Tests Using the SAS System. Cary, NC, SAS Institute, 1999"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.09.005"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29870"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.5633"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4713"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00042307-200303000-00005"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00010-3"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9104-y"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6662"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530260066035"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.2016.72.0748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T10:48:36Z","timestamp":1653821316000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.2016.72.0748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,20]]},"references-count":25,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2017,12,20]]}},"alternative-id":["10.1200\/JCO.2016.72.0748"],"URL":"https:\/\/doi.org\/10.1200\/jco.2016.72.0748","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,20]]},"assertion":[{"value":"2017-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}