{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:36:24Z","timestamp":1790087784819,"version":"4.0.1"},"reference-count":24,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2018,5,1]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Safe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for treatment of adults and children with CML-CP. A phase I study determined suitable dosing for children with Philadelphia chromosome\u2013positive (Ph+) leukemias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CA180-226\/NCT00777036 is a phase II, open-label, nonrandomized prospective trial of patients &lt; 18 years of age receiving dasatinib. There are three cohorts: (1) imatinib-resistant\/intolerant CML-CP, (2) imatinib-resistant\/intolerant CML in accelerated\/blast phase or Ph+ acute lymphoblastic leukemia (n = 17), and (3) newly diagnosed CML-CP treated with tablets or powder for oral suspension. Major cytogenetic response &gt; 30% for imatinib-resistant\/intolerant patients and complete cytogenetic response (CCyR) &gt; 55% for newly diagnosed patients were of clinical interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 113 patients with CML-CP, 14 (48%) who were imatinib-resistant\/intolerant and 61 (73%) who were newly diagnosed remained on treatment at time of analysis. Major cytogenetic response &gt; 30% was reached by 3 months in the imatinib-resistant\/intolerant group and CCyR &gt; 55% was reached by 6 months in the newly diagnosed CML-CP group. CCyR and major molecular response by 12 months, respectively, were 76% and 41% in the imatinib-resistant\/intolerant group and 92% and 52% in newly diagnosed CML-CP group. Progression-free survival by 48 months was 78% and 93% in the imatinib-resistant\/intolerant and newly diagnosed CML-CP groups, respectively. No dasatinib-related pleural or pericardial effusion, pulmonary edema, or pulmonary arterial hypertension were reported. Bone growth and development events were reported in 4% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the largest prospective trial to date in children with CML-CP, we demonstrate that dasatinib is a safe, effective treatment of pediatric CML-CP. Target responses to first- or second-line dasatinib were met early, and deep molecular responses were observed. Safety of dasatinib in pediatric patients was similar to that observed in adults; however, no cases of pleural or pericardial effusion or pulmonary arterial hypertension were reported.<\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.2017.75.9597","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T20:55:38Z","timestamp":1520024138000},"page":"1330-1338","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":95,"title":["Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial"],"prefix":"10.1200","volume":"36","author":[{"given":"Lia","family":"Gore","sequence":"first","affiliation":[{"name":"Lia Gore, University of Colorado School of Medicine\/Children\u2019s Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, S\u00e3o Paulo, Brazil; Yves Bertrand, L'Institut d'H\u00e9matologie et d'Oncologie P\u00e9diatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"Kearns","sequence":"additional","affiliation":[{"name":"Lia Gore, University of Colorado School of Medicine\/Children\u2019s Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, S\u00e3o Paulo, Brazil; Yves Bertrand, L'Institut d'H\u00e9matologie et d'Oncologie P\u00e9diatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lucia","family":"de Martino","sequence":"additional","affiliation":[{"name":"Lia Gore, University of Colorado School of Medicine\/Children\u2019s Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, S\u00e3o Paulo, Brazil; Yves Bertrand, L'Institut d'H\u00e9matologie et d'Oncologie P\u00e9diatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lee","sequence":"additional","affiliation":[{"name":"Lia Gore, University of Colorado School of Medicine\/Children\u2019s Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, S\u00e3o Paulo, Brazil; Yves Bertrand, L'Institut d'H\u00e9matologie et d'Oncologie P\u00e9diatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmino Antonio","family":"De Souza","sequence":"additional","affiliation":[{"name":"Lia Gore, University of Colorado School of Medicine\/Children\u2019s Hospital Colorado, Aurora, CO; Pamela R. 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