{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:36:47Z","timestamp":1791362207238,"version":"4.3.1"},"reference-count":48,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"23","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2018,8,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Mindfulness-based cognitive therapy (MBCT) has been shown to alleviate psychological distress in patients with cancer. However, patients experience barriers to participating in face-to-face MBCT. Individual Internet-based MBCT (eMBCT) could be an alternative. The study aim was to compare MBCT and eMBCT with treatment as usual (TAU) for psychological distress in patients with cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We obtained ethical and safety approval to include 245 patients with cancer with psychological distress (\u2265 11 on the Hospital Anxiety and Depression Scale) in the study. They were randomly allocated to MBCT (n = 77), eMBCT (n = 90), or TAU (n = 78). Patients completed baseline (T0) and postintervention (T1) assessments. The primary outcome was psychological distress on the Hospital Anxiety and Depression Scale. Secondary outcomes were psychiatric diagnosis, fear of cancer recurrence, rumination, health-related quality of life, mindfulness skills, and positive mental health. Continuous outcomes were analyzed using linear mixed modeling on the intention-to-treat sample. Because both interventions were compared with TAU, the type I error rate was set at P &lt; .025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with TAU, patients reported significantly less psychological distress after both MBCT (Cohen\u2019s d, .45; P &lt; .001) and eMBCT (Cohen\u2019s d, .71; P &lt; .001) . In addition, post-treatment prevalence of psychiatric diagnosis was lower with both MBCT (33% improvement; P = .030) and eMBCT (29% improvement; P = .076) in comparison with TAU (16%), but these changes were not statistically significant. Both interventions reduced fear of cancer recurrence and rumination, and increased mental health\u2013related quality of life, mindfulness skills, and positive mental health compared with TAU (all Ps &lt; .025). Physical health\u2013related quality of life did not improve ( P = .343).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared with TAU, MBCT and eMBCT were similarly effective in reducing psychological distress in a sample of distressed heterogeneous patients with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2017.76.5669","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T16:00:19Z","timestamp":1530201619000},"page":"2413-2421","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":251,"title":["Face-to-Face and Internet-Based Mindfulness-Based Cognitive Therapy Compared With Treatment as Usual in Reducing Psychological Distress in Patients With Cancer: A Multicenter Randomized Controlled Trial"],"prefix":"10.1200","volume":"36","author":[{"given":"F\u00e9lix","family":"Compen","sequence":"first","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else","family":"Bisseling","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Schellekens","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier","family":"Donders","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Carlson","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"van der Lee","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Speckens","sequence":"additional","affiliation":[{"name":"F\u00e9lix Compen, Else Bisseling, Melanie Schellekens, Rogier Donders, and Anne Speckens, Radboud University Nijmegen, Nijmegen; F\u00e9lix Compen, Else Bisseling, and Marije van der Lee, Helen Dowling Institute, Bilthoven, the Netherlands; Linda Carlson, University of Calgary, Calgary, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"B1","unstructured":"Bray F: Transitions in human development and the global cancer burden, in Wild CP, Stewart B (eds): World Cancer Report 2014. 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