{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:22:57Z","timestamp":1791868977861,"version":"4.3.4"},"reference-count":36,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2018,7,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Interim positron emission tomography (PET) using the tracer, [\n                      <jats:sup>18<\/jats:sup>\n                      F]fluorodeoxyglucose, may predict outcomes in patients with aggressive non-Hodgkin lymphomas. We assessed whether PET can guide therapy in patients who are treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      Newly diagnosed patients received two cycles of CHOP\u2014plus rituximab (R-CHOP) in CD20-positive lymphomas\u2014followed by a PET scan that was evaluated using the \u0394SUV\n                      <jats:sub>max<\/jats:sub>\n                      method. PET-positive patients were randomly assigned to receive six additional cycles of R-CHOP or six blocks of an intensive Burkitt\u2019s lymphoma protocol. PET-negative patients with CD20-positive lymphomas were randomly assigned or allocated to receive four additional cycles of R-CHOP or the same treatment with two additional doses rituximab. The primary end point was event-free survival time as assessed by log-rank test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Interim PET was positive in 108 (12.5%) and negative in 754 (87.5%) of 862 patients treated, with statistically significant differences in event-free survival and overall survival. Among PET-positive patients, 52 were randomly assigned to R-CHOP and 56 to the Burkitt protocol, with 2-year event-free survival rates of 42.0% (95% CI, 28.2% to 55.2%) and 31.6% (95% CI, 19.3% to 44.6%), respectively (hazard ratio, 1.501 [95% CI, 0.896 to 2.514]; P = .1229). The Burkitt protocol produced significantly more toxicity. Of 754 PET-negative patients, 255 underwent random assignment (129 to R-CHOP and 126 to R-CHOP with additional rituximab). Event-free survival rates were 76.4% (95% CI, 68.0% to 82.8%) and 73.5% (95% CI, 64.8% to 80.4%), respectively (hazard ratio, 1.048 [95% CI, 0.684 to 1.606]; P = .8305). Outcome prediction by PET was independent of the International Prognostic Index. Results in diffuse large B-cell lymphoma were similar to those in the total group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interim PET predicted survival in patients with aggressive lymphomas treated with R-CHOP. PET-based treatment intensification did not improve outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.2017.76.8093","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T15:55:15Z","timestamp":1526054115000},"page":"2024-2034","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":230,"title":["Positron Emission Tomography\u2013Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL): A Multicenter, Randomized Phase III Trial"],"prefix":"10.1200","volume":"36","author":[{"given":"Ulrich","family":"D\u00fchrsen","sequence":"first","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Hertenstein","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Thomssen","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kotzerke","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Mesters","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang E.","family":"Berdel","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Franzius","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Kroschinsky","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Weckesser","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Kofahl-Krause","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M.","family":"Bengel","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"D\u00fcrig","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Matschke","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"P\u00f6ppel","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ose","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"La Ros\u00e9e","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Freesmeyer","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hertel","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; Gabriele Prange-Krex,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz-Gert","family":"H\u00f6ffkes","sequence":"additional","affiliation":[{"name":"Ulrich D\u00fchrsen, Stefan M\u00fcller, Jan D\u00fcrig, Johannes Matschke, Christine Schmitz, Thorsten P\u00f6ppel, Andreas Bockisch, and Andreas H\u00fcttmann, Universit\u00e4tsklinikum Essen; Claudia Ose, Marcus Brinkmann, Karl-Heinz J\u00f6ckel, Andr\u00e9 Scherag, and Jan Rekowski, Universit\u00e4t Duisburg-Essen, Essen; Bernd Hertenstein and Henrike Thomssen, Klinikum Bremen Mitte; Christiane Franzius, Zentrum f\u00fcr moderne Diagnostik, Bremen; J\u00f6rg Kotzerke and Frank Kroschinsky, Universit\u00e4tsklinikum Carl Gustav Carus; 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