{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:13:49Z","timestamp":1793106829347,"version":"4.5.0"},"reference-count":33,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"29","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,10,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>GEM20110714 (ClinicalTrials.gov identifier: NCT01528618 ), the first randomized, phase III study of systemic chemotherapy in recurrent or metastatic nasopharyngeal carcinoma (NPC), reported significant progression-free survival improvement with gemcitabine plus cisplatin (GP) versus fluorouracil plus cisplatin (FP; hazard ratio, 0.55; 95% CI, 0.44 to 0.68; P &lt; .001). Data from the final analysis of overall survival (OS) are presented here.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      From February 2012 to October 2015, 362 patients were randomly assigned to receive either GP (gemcitabine 1 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      once daily on days 1 and 8 and cisplatin 80 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      once daily on day 1; n = 181) or FP (fluorouracil 4 g\/m\n                      <jats:sup>2<\/jats:sup>\n                      in continuous intravenous infusion over 96 hours and cisplatin 80 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      once daily on day 1; n = 181) once every 21 days. The primary end point was progression-free survival, which has been previously reported; OS was a secondary end point.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>After a median follow-up time of 69.5 months with GP and 69.7 months with FP, 148 (81.8%) and 166 (91.7%) deaths occurred in the GP and FP arms, respectively. The estimated hazard ratio for OS was 0.72 (95% CI, 0.58 to 0.90; two-sided P = .004). The median OS was 22.1 months (95% CI, 19.2 to 25.0 months) with GP versus 18.6 months (95% CI, 15.4 to 21.7 months) with FP. The OS probabilities at 1, 3, and 5 years were 79.9% versus 71.8%, 31.0% versus 20.4%, and 19.2% versus 7.8%, respectively. Poststudy therapy was administered in 51.9% and 55.2% of patients in the GP and FP arms, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Among patients with previously untreated advanced nasopharyngeal carcinoma, those who receive GP have longer OS than those receive FP. Gemcitabine plus cisplatin should be considered a preferred front-line option for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.21.00396","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T15:59:19Z","timestamp":1628697559000},"page":"3273-3282","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":107,"title":["Gemcitabine Plus Cisplatin Versus Fluorouracil Plus Cisplatin as First-Line Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: Final Overall Survival Analysis of GEM20110714 Phase III Study"],"prefix":"10.1200","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-6857","authenticated-orcid":false,"given":"Shaodong","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3632-0300","authenticated-orcid":false,"given":"Yaxiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengsheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jiangmen Central Hospital, Jiangmen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-9889","authenticated-orcid":false,"given":"Jiewen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Zhongshan People's Hospital, Zhongshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dongguan People's Hospital, Dongguan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-1908","authenticated-orcid":false,"given":"Xuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Peking University Shenzhen Hospital, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shunde Hospital Guangzhou University of Chinese Medicine, Foshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuping","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Cancer Hospital of Hunan Province, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The First Affiliated Hospital of Gangnan Medical College, Gangnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, 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