{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:07:44Z","timestamp":1791655664980,"version":"4.3.4"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"13","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> GOG-259 was a 3-arm randomized controlled trial of two web-based symptom management interventions for patients with recurrent ovarian cancer. Primary aims were to compare the efficacy of the nurse-guided (Nurse-WRITE) and self-directed (SD-WRITE) interventions to Enhanced Usual Care (EUC) in improving symptoms (burden and controllability) and quality of life (QOL). <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> Patients with recurrent or persistent ovarian, fallopian, or primary peritoneal cancer with 3+ symptoms were eligible for the study. Participants completed baseline (BL) surveys (symptom burden and controllability and QOL) before random assignment. WRITE interventions lasted 8 weeks to develop symptom management plans for three target symptoms. All women received EUC: monthly online symptom assessment with provider reports; online resources; and every 2-week e-mails. Outcomes were evaluated at 8 and 12 weeks after BL. Repeated-measures modeling with linear contrasts evaluated group by time effects on symptom burden, controllability, and QOL, controlling for key covariates. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Participants (N = 497) reported mean age of 59.3 \u00b1 9.2 years. At BL, 84% were receiving chemotherapy and reported a mean of 14.2 \u00b1 4.9 concurrent symptoms, most commonly fatigue, constipation, and peripheral neuropathy. Symptom burden and QOL improved significantly over time ( P &lt; .001) for all three groups. A group by time interaction ( P &lt; .001) for symptom controllability was noted whereby both WRITE intervention groups had similar improvements from BL to 8 and 12 weeks, whereas EUC did not improve over time. <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Both WRITE Intervention groups showed significantly greater improvements in symptom controllability from BL to 8 and BL to 12 weeks compared with EUC. There were no significant differences between Nurse-WRITE and SD-WRITE. SD-WRITE has potential as a scalable intervention for a future implementation study. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.21.00656","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T20:59:37Z","timestamp":1644267577000},"page":"1464-1473","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":24,"title":["Effects of the WRITE Symptoms Interventions on Symptoms and Quality of Life Among Patients With Recurrent Ovarian Cancers: An NRG Oncology\/GOG Study (GOG-0259)"],"prefix":"10.1200","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-8644","authenticated-orcid":false,"given":"Heidi S.","family":"Donovan","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"},{"name":"Magee Womens Hospital of UPMC Hillman Cancer Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-1352","authenticated-orcid":false,"given":"Susan M.","family":"Sereika","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-0349","authenticated-orcid":false,"given":"Lari B.","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Medicine and Public Health, University of California, Irvine, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Magee Womens Hospital of UPMC Hillman Cancer Center, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith E.","family":"Knapp","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Hughes","sequence":"additional","affiliation":[{"name":"University of Wisconsin, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Roberge","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-7314","authenticated-orcid":false,"given":"Teresa H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Jo","family":"Klein","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Nursing, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Spring","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Computing and Information, Pittsburgh, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Nolte","sequence":"additional","affiliation":[{"name":"Abington Memorial Hospital, Gynecologic Oncology Institute, Abington, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Landrum","sequence":"additional","affiliation":[{"name":"Stephenson Cancer Center Gynecologic Cancers Clinic, University of Oklahoma Health Sciences Center, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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