{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:52:27Z","timestamp":1792266747999,"version":"4.4.0"},"reference-count":40,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"28","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> We conducted a phase II study evaluating pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin (pembro-GVD) as second-line therapy for relapsed or refractory (rel\/ref) classical Hodgkin lymphoma (cHL) (ClinicalTrials.gov identifier: NCT03618550 ). <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> Transplant eligible patients with rel\/ref cHL following first-line therapy were treated with two to four cycles of pembrolizumab (200 mg intravenous [IV], day 1), gemcitabine (1,000 mg\/m<jats:sup>2<\/jats:sup> IV, days 1 and 8), vinorelbine (20 mg\/m<jats:sup>2<\/jats:sup> IV, days 1 and 8), and liposomal doxorubicin (15 mg\/m<jats:sup>2<\/jats:sup>, days 1 and 8), given on 21-day cycles. The primary end point was complete response (CR) following up to four cycles of pembro-GVD. Patients who achieved CR by labeled fluorodeoxyglucose-positron emission tomography (Deauville \u2264 3) after two or four cycles proceeded to high-dose therapy and autologous hematopoietic cell transplantation (HDT\/AHCT). HDT\/AHCT was carried out according to institutional standards, and brentuximab vedotin maintenance was allowed following HDT\/AHCT. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Of 39 patients enrolled, 41% had primary ref disease and 38% relapsed within 1 year of frontline treatment. 31 patients received two cycles of pembro-GVD, and eight received four cycles. Most adverse events were grade 1 or two, whereas few were grade 3 and included transaminitis (n = 4), neutropenia (n = 4), mucositis (n = 2), thyroiditis (n = 1), and rash (n = 1). Of 38 evaluable patients, overall and CR rates after pembro-GVD were 100% and 95%, respectively. Thirty-six (95%) patients proceeded to HDT\/AHCT, two received pre-HDT\/AHCT involved site radiation, and 13 (33%) received post-HDT\/AHCT brentuximab vedotin maintenance. All 36 transplanted patients are in remission at a median post-transplant follow-up of 13.5 months (range: 2.66-27.06 months). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Second-line therapy with pembro-GVD is a highly effective and well-tolerated regimen that can efficiently bridge patients with rel\/ref cHL to HDT\/AHCT. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.21.01056","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T19:59:30Z","timestamp":1624651170000},"page":"3109-3117","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":201,"title":["Phase II Trial of Pembrolizumab Plus Gemcitabine, Vinorelbine, and Liposomal Doxorubicin as Second-Line Therapy for Relapsed or Refractory Classical Hodgkin Lymphoma"],"prefix":"10.1200","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3408-050X","authenticated-orcid":false,"given":"Alison 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