{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:44:38Z","timestamp":1792683878970,"version":"4.5.0"},"reference-count":30,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"20","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2022,7,10]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>A combination of anti\u2013B-cell maturation antigen (BCMA) and anti-CD19 chimeric antigen receptor (CAR) T cells induced high response rates in patients with relapsed or refractory (R\/R) multiple myeloma (MM), but long-term outcomes have not been assessed yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>\n                      In this single-arm, phase II trial, patients with R\/R MM received a combination of anti-BCMA CAR T cells and anti-CD19 CAR T cells at a dose of 1 \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/kg, after receiving a conditioning chemotherapy consisting of cyclophosphamide and fludarabine. The overall response, long-term outcomes, and safety were assessed, as were their associations with clinical and disease characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 69 enrolled patients, 62 received the combined infusion of anti-BCMA and anti-CD19 CAR T cells with a median follow-up of 21.3 months. The overall response rate was 92% (57\/62), and complete response or better was observed in 37 patients (60%). Minimal residual disease\u2013negativity was confirmed in 77% (43\/56) of the patients with available minimal residual disease detection. The estimated median duration of response was 20.3 months (95% CI, 9.1 to 31.5). The median progression-free survival was 18.3 months (95% CI, 9.9 to 26.7), and the median overall survival was not reached. Patients with extramedullary disease had significantly inferior survival. Fifty-nine patients (95%) had cytokine release syndrome, with 10% grade 3 or higher. Neurotoxic events occurred in seven patients (11%), including 3% grade 3 or higher. Late adverse effects were rare, except for B-cell aplasia, hypogammaglobulinemia, and infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The combination of anti-BCMA and anti-CD19 CAR T cells induced durable response in patients with R\/R MM, with a median progression-free survival of 18.3 months and a manageable long-term safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.21.01676","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T15:59:45Z","timestamp":1648223985000},"page":"2246-2256","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":120,"title":["Long-Term Follow-Up of Combination of B-Cell Maturation Antigen and CD19 Chimeric Antigen Receptor T Cells in Multiple Myeloma"],"prefix":"10.1200","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-1084","authenticated-orcid":false,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China"},{"name":"Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"},{"name":"Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-9283","authenticated-orcid":false,"given":"Jiang","family":"Cao","sequence":"additional","affiliation":[{"name":"Blood Diseases Institute, Xuzhou Medical University, Xuzhou, China"},{"name":"Department of Hematology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China"},{"name":"Jiangsu Key Laboratory of Bone Marrow Stem Cells, Xuzhou, Jiangsu, 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