{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:51:01Z","timestamp":1792180261487,"version":"4.4.0"},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"25","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Neoadjuvant chemotherapy plus nivolumab has been shown to be effective in resectable non\u2013small-cell lung cancer (NSCLC) in the NADIM trial (ClinicalTrials.gov identifier: NCT03081689 ). The 3-year overall survival (OS) and circulating tumor DNA (ctDNA) analysis have not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This was an open-label, multicenter, single-arm, phase II trial in which patients with stage IIIA NSCLC, who were deemed to be surgically resectable, were treated with neoadjuvant paclitaxel (200 mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      once a day) and carboplatin (area under curve 6) plus nivolumab (360 mg) once on day 1 of each 21-day cycle, for three cycles, followed by adjuvant nivolumab monotherapy for 1 year (240 mg once every 2 weeks for 4 months, followed by 480 mg once every 4 weeks for 8 months). The 3-year OS and ctDNA analysis were secondary objectives of the trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>OS at 36 months was 81.9% (95% CI, 66.8 to 90.6) in the intention-to-treat population, rising to 91.0% (95% CI, 74.2 to 97.0) in the per-protocol population. Neither tumor mutation burden nor programmed cell death ligand-1 staining was predictive of survival. Conversely, low pretreatment levels of ctDNA were significantly associated with improved progression-free survival and OS (hazard ratio [HR], 0.20; 95% CI, 0.06 to 0.63, and HR, 0.07; 95% CI, 0.01 to 0.39, respectively). Clinical responses according to RECIST v1.1 criteria did not predict survival outcomes. However, undetectable ctDNA levels after neoadjuvant treatment were significantly associated with progression-free survival and OS (HR, 0.26; 95% CI, 0.07 to 0.93, and HR, 0.04; 95% CI, 0.00 to 0.55, respectively). The C-index to predict OS for ctDNA levels after neoadjuvant treatment (0.82) was superior to that of RECIST criteria (0.72).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The efficacy of neoadjuvant chemotherapy plus nivolumab in resectable NSCLC is supported by 3-year OS. ctDNA levels were significantly associated with OS and outperformed radiologic assessments in the prediction of survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.21.02660","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T15:59:22Z","timestamp":1652716762000},"page":"2924-2933","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":312,"title":["Overall Survival and Biomarker Analysis of Neoadjuvant Nivolumab Plus Chemotherapy in Operable Stage IIIA Non\u2013Small-Cell Lung Cancer (NADIM phase II trial)"],"prefix":"10.1200","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-7919","authenticated-orcid":false,"given":"Mariano","family":"Provencio","sequence":"first","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Serna-Blasco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-5554","authenticated-orcid":false,"given":"Ernest","family":"Nadal","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d'Oncologia, L'Hospitalet De Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3438-6170","authenticated-orcid":false,"given":"Amelia","family":"Insa","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n INCLIVA, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-7533","authenticated-orcid":false,"given":"M. Rosario","family":"Garc\u00eda-Campelo","sequence":"additional","affiliation":[{"name":"Hospital Universitario A Coru\u00f1a, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Casal Rubio","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Vigo, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1128-434X","authenticated-orcid":false,"given":"Manuel","family":"D\u00f3mine","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Majem","sequence":"additional","affiliation":[{"name":"Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0506-1366","authenticated-orcid":false,"given":"Delvys","family":"Rodr\u00edguez-Abreu","sequence":"additional","affiliation":[{"name":"Hospital Insular de Gran Canaria, Las Palmas, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6714-9526","authenticated-orcid":false,"given":"Alex","family":"Mart\u00ednez-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebron Institute of Oncology (VHIO), Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3622-6306","authenticated-orcid":false,"given":"Javier","family":"De Castro Carpe\u00f1o","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Cobo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Regional de Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"L\u00f3pez Vivanco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cruces, Barakaldo, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edel","family":"Del Barco","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca, Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes","family":"Bernab\u00e9 Caro","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Rocio, Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vi\u00f1olas","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidoro","family":"Barneto Aranda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sofia, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-1123","authenticated-orcid":false,"given":"Santiago","family":"Viteri","sequence":"additional","affiliation":[{"name":"Instituto Oncol\u00f3gico Dr Rosell. Hospital Universitario Quiron Dexeus, Grupo QuironSalud, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Pereira","sequence":"additional","affiliation":[{"name":"Spanish Lung Cancer Group, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-081X","authenticated-orcid":false,"given":"Ana","family":"Royuela","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Calvo","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-3689","authenticated-orcid":false,"given":"Javier","family":"Mart\u00edn-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-5636","authenticated-orcid":false,"given":"Francisco","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Principe Felipe, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-9552","authenticated-orcid":false,"given":"Marta","family":"Casarrubios","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-5136","authenticated-orcid":false,"given":"Fernando","family":"Franco","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2805-0312","authenticated-orcid":false,"given":"Estela","family":"S\u00e1nchez-Herrero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"},{"name":"Atrys Health, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-3952","authenticated-orcid":false,"given":"Bartomeu","family":"Massuti","sequence":"additional","affiliation":[{"name":"Hospital General de Alicante, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-7011","authenticated-orcid":false,"given":"Alberto","family":"Cruz-Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1634-7397","authenticated-orcid":false,"given":"Atocha","family":"Romero","sequence":"additional","affiliation":[{"name":"Hospital Universitario Puerta de Hierro-Majadahonda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01281-7"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801946"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30453-8"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62159-5"},{"key":"b8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41698-019-0106-1","volume":"4","author":"Ling Y","year":"2020","journal-title":"NPJ Precis Oncol"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy218"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-2379"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601118"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyy013"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1000"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430047030"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201400061"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03136"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.09.017"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2360"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2021-CT003"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000879"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70158-X"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70334-6"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.11.017"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01188-3"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1200"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.491"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30641-0"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00276"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0306"},{"key":"b31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lungcan.2021.01.005","volume":"153","author":"Provencio M","year":"2021","journal-title":"Lung Cancer"},{"key":"b32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.02.031"},{"key":"b33","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1424675"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx766"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1127"},{"key":"b36","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"b37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510665"},{"key":"b38","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2021.05.014"},{"key":"b39","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.8500"},{"key":"b40","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00004-8"}],"updated-by":[{"DOI":"10.1200\/jco.22.02137","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000}}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.21.02660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T08:20:52Z","timestamp":1664353252000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.21.02660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":39,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2022,9,1]]}},"alternative-id":["10.1200\/JCO.21.02660"],"URL":"https:\/\/doi.org\/10.1200\/jco.21.02660","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742152019.793596808","asserted-by":"object"}]},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]},"assertion":[{"value":"2021-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}