{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:06:29Z","timestamp":1793919989136,"version":"4.8.0"},"reference-count":41,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2023,1,10]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> To determine the specific types, durations, and intensities of recreational physical activity associated with the greatest improvements in disease-free survival (DFS) of patients with colon cancer. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> We conducted a prospective cohort study nested within a randomized multicenter trial of stage III colon cancer that compared 3 versus 6 months of fluorouracil, leucovorin, and oxaliplatin with or without celecoxib. We measured recreational physical activity in the first 3 months of chemotherapy and again 6 months after completion of chemotherapy. The primary end point was DFS. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> During a median follow-up of 5.9 years, 457 of 1,696 patients experienced disease recurrence or death. For total recreational physical activity volume, the 3-year DFS was 76.5% with &lt; 3.0 metabolic equivalent task hours per week (MET-h\/wk) and 87.1% with \u2265 18.0 MET-h\/wk (risk difference [RD], 10.6%; 95% CI, 4.7 to 19.4; P &lt; .001). For light-intensity to moderate-intensity activities, the 3-year DFS was 65.7% with 0.0 h\/wk and 87.1% with \u2265 1.5 h\/wk (RD, 21.4%; 95% CI, 9.2 to 37.1; P &lt; .001). For vigorous-intensity activity, the 3-year DFS was 76.0% with 0.0 h\/wk and 86.0% with \u2265 1.0 h\/wk (RD, 10.0%; 95% CI, 4.5 to 18.9; P &lt; .001). For brisk walking, the 3-year DFS was 81.7% with &lt; 1.0 h\/wk and 88.4% with \u2265 3.0 h\/wk (RD, 6.7%; 95% CI, 3.0 to 13.8; P &lt; .001). For muscle strengthening activity, the 3-year DFS was 81.8% with 0.0 h\/wk and 88.8% for \u2265 0.5 h\/wk (RD, 7.0%; 95% CI, 3.1 to 14.2; P = .003). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Among patients with stage III colon cancer enrolled in a trial of postoperative treatment, larger volumes of recreational physical activity, longer durations of light- to moderate-intensity aerobic physical activity, or any vigorous-intensity aerobic physical activity were associated with the greatest improvements in DFS. <\/jats:p><\/jats:sec>","DOI":"10.1200\/jco.22.00171","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T20:01:11Z","timestamp":1660075271000},"page":"243-254","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":39,"title":["Physical Activity in Stage III Colon Cancer: CALGB\/SWOG 80702 (Alliance)"],"prefix":"10.1200","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7540-4913","authenticated-orcid":false,"given":"Justin C.","family":"Brown","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, LA"},{"name":"LSU Health Sciences Center New Orleans School of Medicine, New Orleans, LA"},{"name":"Stanley S. 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