{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:32:15Z","timestamp":1793939535692,"version":"4.8.0"},"reference-count":31,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"3","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO"],"published-print":{"date-parts":[[2023,1,20]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>The CHOICE-01 study investigated the efficacy and safety of toripalimab in combination with chemotherapy as a first-line treatment for advanced non\u2013small-cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS AND METHODS<\/jats:title>\n                    <jats:p>Patients (N = 465) with treatment-naive, advanced NSCLC without EGFR\/ALK mutations were randomly assigned 2:1 to receive toripalimab 240 mg (n = 309) or placebo (n = 156) once every 3 weeks in combination with chemotherapy for 4-6 cycles, followed by the maintenance of toripalimab or placebo once every 3 weeks plus standard care. Stratification factors included programmed death ligand-1 expression status, histology, and smoking status. The primary end point was progression-free survival (PFS) by investigator per RECIST v1.1. Secondary end points included overall survival and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At the final PFS analysis, PFS was significantly longer in the toripalimab arm than in the placebo arm (median PFS, 8.4 v 5.6 months, hazard ratio = 0.49; 95% CI, 0.39 to 0.61; two-sided P &lt; .0001). At the interim OS analysis, the toripalimab arm had a significantly longer OS than the placebo arm (median OS not reached v 17.1 months, hazard ratio = 0.69; 95% CI, 0.53 to 0.92; two-sided P = .0099). The incidence of grade \u2265 3 adverse events was similar between the two arms. Treatment effects were similar regardless of programmed death ligand-1 status. Genomic analysis using whole-exome sequencing from 394 available tumor samples revealed that patients with high tumor mutational burden were associated with significantly better PFS in the toripalimab arm (median PFS 13.1 v 5.5 months, interaction P = .026). Notably, patients with mutations in the focal adhesion-PI3K-Akt signaling pathway achieved significantly better PFS and OS in the toripalimab arm (interaction P values \u2264 .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Toripalimab plus chemotherapy significantly improves PFS and OS in patients with treatment-naive advanced NSCLC while having a manageable safety profile. Subgroup analysis showed the OS benefit was mainly driven by the nonsquamous subpopulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/jco.22.00727","type":"journal-article","created":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T16:00:14Z","timestamp":1665158414000},"page":"651-663","update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":173,"title":["Toripalimab Plus Chemotherapy for Patients With Treatment-Naive Advanced Non\u2013Small-Cell Lung Cancer: A Multicenter Randomized Phase III Trial (CHOICE-01)"],"prefix":"10.1200","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct03856411","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Zhijie","family":"Wang","sequence":"first","affiliation":[{"name":"CAMS Key Laboratory of Translational Research on Lung Cancer, State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-7767","authenticated-orcid":false,"given":"Lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Chest Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-597X","authenticated-orcid":false,"given":"Ying","family":"Cheng","sequence":"additional","affiliation":[{"name":"Jilin Cancer Hospital, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Cancer Hospital & Institute, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicheng","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, School of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Han","sequence":"additional","affiliation":[{"name":"Xuzhou Central Hospital, Xuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Jiangnan University Affiliated Hospital, Wuxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Fan","sequence":"additional","affiliation":[{"name":"Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Harbin Medical University Cancer Hospital, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqing","family":"Lv","sequence":"additional","affiliation":[{"name":"Taizhou Hospital of Zhejiang Province, Linhai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Shi","sequence":"additional","affiliation":[{"name":"Linyi Cancer Hospital, Linyi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjin","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Affiliated Tumor Hospital, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohui","family":"Han","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guogui","family":"Sun","sequence":"additional","affiliation":[{"name":"Tangshan People's Hospital, Tangshan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisen","family":"Guo","sequence":"additional","affiliation":[{"name":"Shangdong Cancer Hospital, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youxin","family":"Ji","sequence":"additional","affiliation":[{"name":"Qingdao Central Hospital, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhongda Hospital Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Hubei Cancer Hospital, Wuhan, China,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-2885","authenticated-orcid":false,"given":"Qiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Cancer Hospital, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Jia","sequence":"additional","affiliation":[{"name":"The Second People's Hospital of Yibin, Yibin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziping","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Cancer Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Song","sequence":"additional","affiliation":[{"name":"Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxun","family":"Wu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Jiangsu Cancer Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingya","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Han","sequence":"additional","affiliation":[{"name":"Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-135X","authenticated-orcid":false,"given":"Zhuang","family":"Yu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Qingdao University, Qingdao, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang University, Nanchang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caicun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Pulmonary Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diansheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-3244","authenticated-orcid":false,"given":"Liyun","family":"Miao","sequence":"additional","affiliation":[{"name":"Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anhui Provincial Cancer Hospital, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"Army Medical Center of PLA, Daping Hospital, Daping, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking Union Medical College Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai East Hospital of Tongji University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nantong Tumor Hospital, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Ji","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Changzhou, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhou","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuwei","family":"Cui","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beili","family":"Gao","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiaotong University, School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buhai","family":"Wang","sequence":"additional","affiliation":[{"name":"Subei People's Hospital of Jiangsu Province, Yanghzou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-6868","authenticated-orcid":false,"given":"Hu","family":"Liu","sequence":"additional","affiliation":[{"name":"Anhui Provincial Cancer Hospital, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Nie","sequence":"additional","affiliation":[{"name":"Shanxi Provincial Tumor Hospital, Xian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4502-6362","authenticated-orcid":false,"given":"Mei","family":"He","sequence":"additional","affiliation":[{"name":"Shanxi Provincial People's Hospital, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Jin","sequence":"additional","affiliation":[{"name":"Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-9845","authenticated-orcid":false,"given":"Wei","family":"Gu","sequence":"additional","affiliation":[{"name":"Nanjing First Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"ChangZhou Cancer Hospital, Changzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Feng","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nantong University, Nantong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Jiaxing No. 1 Hospital, Jiaxing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Cancer Hospital, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xinqiao Hospital of Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yao","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Xi'an Jiaotong University, Xian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-5197","authenticated-orcid":false,"given":"Xiongwen","family":"Tang","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"},{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yu","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Maher","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Feng","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"},{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-9937","authenticated-orcid":false,"given":"Sheng","family":"Yao","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"},{"name":"Shanghai Junshi Biosciences, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7266-395X","authenticated-orcid":false,"given":"Patricia","family":"Keegan","sequence":"additional","affiliation":[{"name":"TopAlliance Biosciences, Rockville, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5602-0487","authenticated-orcid":false,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"CAMS Key Laboratory of Translational Research on Lung Cancer, State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"b1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60735-0"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12197"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30167-6"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810865"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"b7","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12068"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3922"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02712"},{"key":"b10","volume":"38","author":"Sheng X","year":"2020","journal-title":"J Clin Oncol"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01444-0"},{"key":"b12","first-page":"681","volume":"11","author":"Liu H","year":"2019","journal-title":"MAbs"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.161"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.13770"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.01.028"},{"key":"b16","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0160-6"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.03.018"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1348"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0200-2"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70054-9"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz197"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.02.007"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.11.025"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03136"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.06.015"},{"key":"b27","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4123"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22933"},{"key":"b29","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan5951"},{"key":"b30","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-020-0112-3"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.e20690"}],"container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.22.00727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T18:03:03Z","timestamp":1673978583000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.22.00727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,1,20]]}},"alternative-id":["10.1200\/JCO.22.00727"],"URL":"https:\/\/doi.org\/10.1200\/jco.22.00727","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"2022-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}